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First published online 6 October 2004
doi: 10.1242/dev.01410

Development 131, 5457-5468 (2004)
Published by The Company of Biologists 2004
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accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA1

Hiromi Hirata1, Louis Saint-Amant1, Julie Waterbury3, Wilson Cui1, Weibin Zhou1, Qin Li1, Daniel Goldman2, Michael Granato3 and John Y. Kuwada1,*

1 Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-0720, USA
2 Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109-0720, USA
3 Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6058, USA

* Author for correspondence (e-mail: kuwada{at}umich.edu)

Accepted 16 August 2004

When wild-type zebrafish embryos are touched at 24 hours post-fertilization (hpf), they typically perform two rapid alternating coils of the tail. By contrast, accordion (acc) mutants fail to coil their tails normally but contract the bilateral trunk muscles simultaneously to shorten the trunk, resulting in a pronounced dorsal bend. Electrophysiological recordings from muscles showed that the output from the central nervous system is normal in mutants, suggesting a defect in muscles is responsible. In fact, relaxation in acc muscle is significantly slower than normal. In vivo imaging of muscle Ca2+ transients revealed that cytosolic Ca2+ decay was significantly slower in acc muscle. Thus, it appears that the mutant behavior is caused by a muscle relaxation defect due to the impairment of Ca2+ re-uptake. Indeed, acc mutants carry a mutation in atp2a1 gene that encodes the sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA1), a Ca2+ pump found in the muscle sarcoplasmic reticulum (SR) that is responsible for pumping Ca2+ from the cytosol back to the SR. As SERCA1 mutations in humans lead to Brody disease, an exercise-induced muscle relaxation disorder, zebrafish accordion mutants could be a useful animal model for this condition.

Key words: Zebrafish, Accordion, Behavior, Muscle, Calcium, SERCA1, Brody diseasea


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