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First published online 3 November 2004
doi: 10.1242/dev.01460

Development 131, 5849-5857 (2004)
Published by The Company of Biologists 2004
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Temporal complexity within a translational control element in the nanos mRNA

Kevin M. Forrest, Ira E. Clark, Roshan A. Jain and Elizabeth R. Gavis*

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA

* Author for correspondence (e-mail: lgavis{at}molbio.princeton.edu)

Accepted 21 September 2004

Translational control of gene expression plays a fundamental role in the early development of many organisms. In Drosophila, selective translation of nanos mRNA localized to the germ plasm at the posterior of the embryo, together with translational repression of nanos in the bulk cytoplasm, is essential for development of the anteroposterior body pattern. We show that both components to spatial control of nanos translation initiate during oogenesis and that translational repression is initially independent of Smaug, an embryonic repressor of nanos. Repression during oogenesis and embryogenesis are mediated by distinct stem loops within the nanos 3' untranslated region; the Smaug-binding stem-loop acts strictly in the embryo, whereas a second stem-loop functions in the oocyte. Thus, independent regulatory modules with temporally distinct activities contribute to spatial regulation of nanos translation. We propose that nanos evolved to exploit two different stage-specific translational regulatory mechanisms.

Key words: nanos, Translational control, Translational regulation, Translational repressor, Drosophila, Oogenesis, Embryogenesis, Maternal mRNA




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