|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online 10 November 2004
doi: 10.1242/dev.01532
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
3ß1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development
1 UNC Neuroscience Center and the Department of Cell and Molecular Physiology,
The University of North Carolina School of Medicine, Chapel Hill, NC 27599,
USA
2 Department of Biological Sciences, Stanford University, Stanford, CA 94305,
USA
3 Department of Medicine, Children's Hospital, Boston and Department of
Pediatrics, Harvard Medical School, Boston, MA 02115, USA
* Author for correspondence (e-mail: anton{at}med.unc.edu)
Accepted 29 September 2004
We show that 
3 integrin mutation disrupts distinct aspects of
neuronal migration and placement in the cerebral cortex. The preplate develops
normally in 3 integrin mutant mice. However, time lapse imaging of
migrating neurons in embryonic cortical slices indicates retarded radial and
tangential migration of neurons, but not ventricular zone-directed migration.
Examination of the actin cytoskeleton of 3 integrin mutant cortical
cells reveals aberrant actin cytoskeletal dynamics at the leading edges.
Deficits are also evident in the ability of developing neurons to probe their
cellular environment with filopodial and lamellipodial activity. Calbindin or
calretinin positive upper layer neurons as well as the deep layer neurons of
3 integrin mutant mice expressing EGFP were misplaced. These results
suggest that 3ß1 integrin deficiency impairs distinct patterns of
neuronal migration and placement through dysregulated actin dynamics and
defective ability to search and respond to migration modulating cues in the
developing cortex.
Key words: Cerebral cortex, Migration, Adhesion
This article has been cited by other articles:
|
|
 |
|
  R. Belvindrah, D. Graus-Porta, S. Goebbels, K.-A. Nave, and U. Muller 1 Integrins in Radial Glia But Not in Migrating Neurons Are Essential for the Formation of Cell Layers in the Cerebral Cortex J. Neurosci., December 12, 2007; 27(50): 13854 - 13865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Jossin and A. M. Goffinet Reelin Signals through Phosphatidylinositol 3-Kinase and Akt To Control Cortical Development and through mTor To Regulate Dendritic Growth Mol. Cell. Biol., October 15, 2007; 27(20): 7113 - 7124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Hirai, D. Feng Cui, T. Miyata, M. Ogawa, H. Kiyonari, Y. Suda, S. Aizawa, Y. Banba, and S. Ohno The c-Jun N-Terminal Kinase Activator Dual Leucine Zipper Kinase Regulates Axon Growth and Neuronal Migration in the Developing Cerebral Cortex. J. Neurosci., November 15, 2006; 26(46): 11992 - 12002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Huang, K. Shimazu, N. H. Woo, K. Zang, U. Muller, B. Lu, and L. F. Reichardt Distinct Roles of the beta1-Class Integrins at the Developing and the Mature Hippocampal Excitatory Synapse J. Neurosci., October 25, 2006; 26(43): 11208 - 11219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Schmid, R. Jo, S. Shelton, J. A. Kreidberg, and E. S. Anton Reelin, Integrin and Dab1 Interactions during Embryonic Cerebral Cortical Development Cereb Cortex, October 1, 2005; 15(10): 1632 - 1636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Niewmierzycka, J. Mills, R. St-Arnaud, S. Dedhar, and L. F. Reichardt Integrin-Linked Kinase Deletion from Mouse Cortex Results in Cortical Lamination Defects Resembling Cobblestone Lissencephaly J. Neurosci., July 27, 2005; 25(30): 7022 - 7031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Perez-Martinez and D. M. Jaworski Tissue Inhibitor of Metalloproteinase-2 Promotes Neuronal Differentiation by Acting as an Anti-Mitogenic Signal J. Neurosci., May 18, 2005; 25(20): 4917 - 4929. [Abstract] [Full Text] [PDF]
|
|
