spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 10 November 2004
doi: 10.1242/dev.01521

Development 131, 6093-6105 (2004)
Published by The Company of Biologists 2004
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01521v1
131/24/6093    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miguel-Aliaga, I.
Right arrow Articles by Thor, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miguel-Aliaga, I.
Right arrow Articles by Thor, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity

Irene Miguel-Aliaga* and Stefan Thor*,{dagger}

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA

{dagger} Author for correspondence (e-mail: steth{at}ifm.liu.se)

Accepted 6 October 2004

In vertebrates, neurons often undergo apoptosis after differentiating and extending their axons. By contrast, in the developing nervous system of invertebrate embryos apoptosis typically occurs soon after cells are generated. Here, we show that the Drosophila dMP2 and MP1 pioneer neurons undergo segment-specific apoptosis at late embryonic stages, long after they have extended their axons and have performed their pioneering role in guiding follower axons. This segmental specificity is achieved by differential expression of the Hox gene Abdominal B, which in posterior segments prevents pioneer neuron death postmitotically and cell-autonomously by repressing the RHG-motif cell death activators reaper and grim. Our results identify the first clear case of a cell-autonomous and anti-apoptotic role for a Hox gene in vivo. In addition, they provide a novel mechanism linking Hox positional information to differences in neuronal architecture along the anteroposterior axis by the selective elimination of mature neurons.

Key words: Drosophila, Abd-B, reaper, grim, dMP2, MP1


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in Development:

Hox-mediated neuronal patterning: death to pioneers

Development 2004 131: e2401. [Full Text]  



This article has been cited by other articles:


Home page
 DevelopmentHome page
A. Kumar, B. Bello, and H. Reichert
Lineage-specific cell death in postembryonic brain development of Drosophila
Development, October 15, 2009; 136(20): 3433 - 3442.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. R. Wheeler, S. Banerjee, K. Blauth, S. L. Rogers, M. A. Bhat, and S. T. Crews
Neurexin IV and Wrapper interactions mediate Drosophila midline glial migration and axonal ensheathment
Development, April 1, 2009; 136(7): 1147 - 1157.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Palgi, R. Lindstrom, J. Peranen, T. P. Piepponen, M. Saarma, and T. I. Heino
Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons
PNAS, February 17, 2009; 106(7): 2429 - 2434.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Rogulja-Ortmann, S. Renner, and G. M. Technau
Antagonistic roles for Ultrabithorax and Antennapedia in regulating segment-specific apoptosis of differentiated motoneurons in the Drosophila embryonic central nervous system
Development, October 15, 2008; 135(20): 3435 - 3445.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P.-L. Bardet, G. Kolahgar, A. Mynett, I. Miguel-Aliaga, J. Briscoe, P. Meier, and J.-P. Vincent
A fluorescent reporter of caspase activity for live imaging
PNAS, September 16, 2008; 105(37): 13901 - 13905.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Z. Parrish, K. Emoto, L. Y. Jan, and Y. N. Jan
Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites
Genes & Dev., April 15, 2007; 21(8): 956 - 972.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Rogulja-Ortmann, K. Luer, J. Seibert, C. Rickert, and G. M. Technau
Programmed cell death in the embryonic central nervous system of Drosophila melanogaster
Development, January 1, 2007; 134(1): 105 - 116.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. P.-s. Luke, G. Sui, H. Liu, and Y. Shi
Yin Yang 1 Physically Interacts with Hoxa11 and Represses Hoxa11-dependent Transcription
J. Biol. Chem., November 3, 2006; 281(44): 33226 - 33232.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Garces and S. Thor
Specification of Drosophila aCC motoneuron identity by a genetic cascade involving even-skipped, grain and zfh1
Development, April 15, 2006; 133(8): 1445 - 1455.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Liu, T. J. Strauss, M. B. Potts, and S. Cameron
Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1
Development, February 15, 2006; 133(4): 641 - 650.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004