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First published online February 18, 2004
doi: 10.1242/10.1242/dev.00980

Development 131, 1007-1016 (2004)
Published by The Company of Biologists 2004
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Drosophila Twins regulates Armadillo levels in response to Wg/Wnt signal

Ruchi Bajpai*,{dagger}, Kalpana Makhijani*, Prashanth Ramesh Rao and L. S. Shashidhara{dagger}

Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India

{dagger} Authors for correspondence (e-mail: shashi{at}ccmb.res.in)

Accepted 12 November 2003

Protein Phosphatase 2A (PP2A) has a heterotrimeric-subunit structure, consisting of a core dimer of ~36 kDa catalytic and ~65 kDa scaffold subunits complexed to a third variable regulatory subunit. Several studies have implicated PP2A in Wg/Wnt signaling. However, reports on the precise nature of PP2A role in Wg/Wnt pathway in different organisms are conflicting. We show that twins (tws), which codes for the B/PR55 regulatory subunit of PP2A in Drosophila, is a positive regulator of Wg/Wnt signaling. In tws- wing discs both short- and long-range targets of Wingless morphogen are downregulated. Analyses of tws- mitotic clones suggest that requirement of Tws in Wingless pathway is cell-autonomous. Epistatic genetic studies indicate that Tws functions downstream of Dishevelled and upstream of Sgg and Armadillo. Our results suggest that Tws is required for the stabilization of Armadillo/ß-catenin in response to Wg/Wnt signaling. Interestingly, overexpression of, otherwise normal, Tws protein induce dominant-negative phenotypes. The conflicting reports on the role of PP2A in Wg/Wnt signaling could be due to the dominant-negative effect caused by the overexpression of one of the subunits.

Key words: Drosophila, Arm, Wg


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