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First published online February 18, 2004
doi: 10.1242/10.1242/dev.01074

Development 131, 965-973 (2004)
Published by The Company of Biologists 2004
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Primer

Notch signaling: control of cell communication and cell fate

Eric C. Lai

Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA e-mail: lai{at}fruitfly.org

SUMMARY

Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.




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