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First published online February 18, 2004
doi: 10.1242/10.1242/dev.01074

Development 131, 965-973 (2004)
Published by The Company of Biologists 2004
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Primer

Notch signaling: control of cell communication and cell fate

Eric C. Lai

Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA e-mail: lai{at}fruitfly.org

SUMMARY

Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.


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M. Gause, J. C. Eissenberg, A. F. MacRae, M. Dorsett, Z. Misulovin, and D. Dorsett
Nipped-A, the Tra1/TRRAP Subunit of the Drosophila SAGA and Tip60 Complexes, Has Multiple Roles in Notch Signaling during Wing Development.
Mol. Cell. Biol., March 1, 2006; 26(6): 2347 - 2359.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
T. Ohyama, O. A. Mohamed, M. M. Taketo, D. Dufort, and A. K. Groves
Wnt signals mediate a fate decision between otic placode and epidermis
Development, March 1, 2006; 133(5): 865 - 875.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
L. Miele
Notch Signaling
Clin. Cancer Res., February 15, 2006; 12(4): 1074 - 1079.
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 Mol. Cell. Biol.Home page
F. Oswald, M. Winkler, Y. Cao, K. Astrahantseff, S. Bourteele, W. Knochel, and T. Borggrefe
RBP-J{kappa}/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes
Mol. Cell. Biol., December 1, 2005; 25(23): 10379 - 10390.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
J. Akai, P. A. Halley, and K. G. Storey
FGF-dependent Notch signaling maintains the spinal cord stem zone
Genes & Dev., December 1, 2005; 19(23): 2877 - 2887.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
S. J. Macdonald, T. Pastinen, and A. D. Long
The Effect of Polymorphisms in the Enhancer of split Gene Complex on Bristle Number Variation in a Large Wild-Caught Cohort of Drosophila melanogaster
Genetics, December 1, 2005; 171(4): 1741 - 1756.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
I. Alvarez-Garcia and E. A. Miska
MicroRNA functions in animal development and human disease
Development, November 1, 2005; 132(21): 4653 - 4662.
[Abstract] [Full Text] [PDF]

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 Physiol. Rev.Home page
A. Leri, J. Kajstura, and P. Anversa
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Physiol Rev, October 1, 2005; 85(4): 1373 - 1416.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
A. E. Kiernan, R. Cordes, R. Kopan, A. Gossler, and T. Gridley
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
Development, October 1, 2005; 132(19): 4353 - 4362.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
C. Pitsouli and C. Delidakis
The interplay between DSL proteins and ubiquitin ligases in Notch signaling
Development, September 15, 2005; 132(18): 4041 - 4050.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
A. Xu, L. Lei, and K. D. Irvine
Regions of Drosophila Notch That Contribute to Ligand Binding and the Modulatory Influence of Fringe
J. Biol. Chem., August 26, 2005; 280(34): 30158 - 30165.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
B. Castro, S. Barolo, A. M. Bailey, and J. W. Posakony
Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless
Development, August 1, 2005; 132(15): 3333 - 3344.
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 DevelopmentHome page
B.-K. Koo, H.-S. Lim, R. Song, M.-J. Yoon, K.-J. Yoon, J.-S. Moon, Y.-W. Kim, M.-c. Kwon, K.-W. Yoo, M.-P. Kong, et al.
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch
Development, August 1, 2005; 132(15): 3459 - 3470.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
J. A. Armstrong, A. S. Sperling, R. Deuring, L. Manning, S. L. Moseley, O. Papoulas, C. I. Piatek, C. Q. Doe, and J. W. Tamkun
Genetic Screens for Enhancers of brahma Reveal Functional Interactions Between the BRM Chromatin-Remodeling Complex and the Delta-Notch Signal Transduction Pathway in Drosophila
Genetics, August 1, 2005; 170(4): 1761 - 1774.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
E. Mizuhara, T. Nakatani, Y. Minaki, Y. Sakamoto, Y. Ono, and Y. Takai
MAGI1 Recruits Dll1 to Cadherin-based Adherens Junctions and Stabilizes It on the Cell Surface
J. Biol. Chem., July 15, 2005; 280(28): 26499 - 26507.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
T. R. Carlson, Y. Yan, X. Wu, M. T. Lam, G. L. Tang, L. J. Beverly, L. M. Messina, A. J. Capobianco, Z. Werb, and R. Wang
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice
PNAS, July 12, 2005; 102(28): 9884 - 9889.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. S. Vetrivel, H. Cheng, S.-H. Kim, Y. Chen, N. Y. Barnes, A. T. Parent, S. S. Sisodia, and G. Thinakaran
Spatial Segregation of {gamma}-Secretase and Substrates in Distinct Membrane Domains
J. Biol. Chem., July 8, 2005; 280(27): 25892 - 25900.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
M. Yamaguchi, N. Tonou-Fujimori, A. Komori, R. Maeda, Y. Nojima, H. Li, H. Okamoto, and I. Masai
Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways
Development, July 1, 2005; 132(13): 3027 - 3043.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
V. E. Vought, M. Ohmachi, M.-H. Lee, and E. M. Maine
EGO-1, a Putative RNA-Directed RNA Polymerase, Promotes Germline Proliferation in Parallel With GLP-1/Notch Signaling and Regulates the Spatial Organization of Nuclear Pore Complexes and Germline P Granules in Caenorhabditis elegans
Genetics, July 1, 2005; 170(3): 1121 - 1132.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
T. A. Berset, E. F. Hoier, and A. Hajnal
The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions
Genes & Dev., June 1, 2005; 19(11): 1328 - 1340.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
L. C. Nehring, A. Miyamoto, P. W. Hein, G. Weinmaster, and J. M. Shipley
The Extracellular Matrix Protein MAGP-2 Interacts with Jagged1 and Induces Its Shedding from the Cell Surface
J. Biol. Chem., May 27, 2005; 280(21): 20349 - 20355.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
L. Pan, S. T. Glenn, C. A. Jones, and K. W. Gross
Activation of the Rat Renin Promoter by HOXD10{middle dot}PBX1b{middle dot}PREP1, Ets-1, and the Intracellular Domain of Notch
J. Biol. Chem., May 27, 2005; 280(21): 20860 - 20866.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
E. C. Lai, F. Roegiers, X. Qin, Y. N. Jan, and G. M. Rubin
The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
Development, May 15, 2005; 132(10): 2319 - 2332.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
E. C. Lai, B. Tam, and G. M. Rubin
Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs
Genes & Dev., May 1, 2005; 19(9): 1067 - 1080.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
R. Le Borgne, A. Bardin, and F. Schweisguth
The roles of receptor and ligand endocytosis in regulating Notch signaling
Development, April 15, 2005; 132(8): 1751 - 1762.
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 DevelopmentHome page
K.-i. Mizutani and T. Saito
Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex
Development, March 15, 2005; 132(6): 1295 - 1304.
[Abstract] [Full Text] [PDF]


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