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First published online March 15, 2004
doi: 10.1242/10.1242/dev.01031

Development 131, 1529-1541 (2004)
Published by The Company of Biologists 2004
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Two zebrafish Notch-dependent hairy/Enhancer-of-split-related genes, her6 and her4, are required to maintain the coordination of cyclic gene expression in the presomitic mesoderm

Andrea Pasini1,*,{ddagger}, Yun-Jin Jiang2,{dagger} and David G. Wilkinson1,{ddagger}

1 Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 7AA, UK
2 Vertebrate Development Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK

{ddagger} Authors for correspondence (e-mail: pasini{at}ibdm.univ-mrs.fr and dwilkin{at}nimr.mrc.ac.uk)

Accepted 11 December 2003

Alterations of the Delta/Notch signalling pathway cause multiple morphogenetic abnormalities in somitogenesis, including defects in intersomitic boundary formation and failure in maintenance of somite regularity. Notch signalling has been implicated in establishing the anteroposterior polarity within maturing somites and in regulating the activity of a molecular segmentation clock operating in the presomitic mesoderm. The pleiotropy of Notch signalling obscures the roles of this pathway in different steps of somitogenesis. One possibility is that distinct Notch effectors mediate different aspects of Notch signalling. In this study, we focus on two zebrafish Notch-dependent hairy/Enhancer-of-split-related transcription factors, Her6 and Her4, which are expressed at the transition zone between presomitic mesoderm and the segmented somites. The results of overexpression/gain-of-function and of morpholino-mediated loss-of-function experiments show that Her6 and Her4 are Notch signalling effectors that feedback on the clock and take part in the maintenance of cyclic gene expression coordination among adjacent cells in the presomitic mesoderm.

Key words: Zebrafish, Somites, Notch, Segmentation clock, her6, her4




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