spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online March 30, 2004
doi: 10.1242/10.1242/dev.01117

Development 131, 1663-1677 (2004)
Published by The Company of Biologists 2004
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Figures
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by He, X.
Right arrow Articles by Zeng, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by He, X.
Right arrow Articles by Zeng, X.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Review

LDL receptor-related proteins 5 and 6 in Wnt/ß-catenin signaling: Arrows point the way

Xi He*, Mikhail Semenov, Keiko Tamai and Xin Zeng

Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

* Author for correspondence (e-mail: xi.he{at}childrens.harvard.edu)

SUMMARY

Wnt signaling through the canonical ß-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/ß-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular ß-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
C.-C. Liu, C. Pearson, and G. Bu
Cooperative Folding and Ligand-binding Properties of LRP6 {beta}-Propeller Domains
J. Biol. Chem., May 29, 2009; 284(22): 15299 - 15307.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Jin, J. Shi, A. Saraf, W. Mei, G.-Z. Zhu, S. Strack, and J. Yang
The 48-kDa Alternative Translation Isoform of PP2A:B56{epsilon} Is Required for Wnt Signaling during Midbrain-Hindbrain Boundary Formation
J. Biol. Chem., March 13, 2009; 284(11): 7190 - 7200.
[Abstract] [Full Text] [PDF]

Home page
 IBMS BoneKEyHome page
J. Caverzasio
Non-Canonical Wnt Signaling: What Is Its Role in Bone?
IBMS BoneKEy, March 1, 2009; 6(3): 107 - 115.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
V. Bryja, E. R. Andersson, A. Schambony, M. Esner, L. Bryjova, K. K. Biris, A. C. Hall, B. Kraft, L. Cajanek, T. P. Yamaguchi, et al.
The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo
Mol. Biol. Cell, February 1, 2009; 20(3): 924 - 936.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Lin, C. Gao, Y. Ning, X. He, W. Wu, and Y.-G. Chen
The Pseudoreceptor BMP and Activin Membrane-bound Inhibitor Positively Modulates Wnt/{beta}-Catenin Signaling
J. Biol. Chem., November 28, 2008; 283(48): 33053 - 33058.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Wan, C. Yang, J. Li, X. Wu, H. Yuan, H. Ma, X. He, S. Nie, C. Chang, and X. Cao
Parathyroid hormone signaling through low-density lipoprotein-related protein 6
Genes & Dev., November 1, 2008; 22(21): 2968 - 2979.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. J. Kim, I. V. Chia, and F. Costantini
SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
FASEB J, November 1, 2008; 22(11): 3785 - 3794.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Miech, H.-U. Pauer, X. He, and T. L. Schwarz
Presynaptic Local Signaling by a Canonical Wingless Pathway Regulates Development of the Drosophila Neuromuscular Junction
J. Neurosci., October 22, 2008; 28(43): 10875 - 10884.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Russek-Blum, A. Gutnick, H. Nabel-Rosen, J. Blechman, N. Staudt, R. I. Dorsky, C. Houart, and G. Levkowitz
Dopaminergic neuronal cluster size is determined during early forebrain patterning
Development, October 15, 2008; 135(20): 3401 - 3413.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Wang, Y. Zhang, X. Li, L. Chen, H. Wang, J. Wu, J. Zheng, and D. Wu
Characterization of the Kremen-binding Site on Dkk1 and Elucidation of the Role of Kremen in Dkk-mediated Wnt Antagonism
J. Biol. Chem., August 22, 2008; 283(34): 23371 - 23375.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Ellwanger, H. Saito, P. Clement-Lacroix, N. Maltry, J. Niedermeyer, W. K. Lee, R. Baron, G. Rawadi, H. Westphal, and C. Niehrs
Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density
Mol. Cell. Biol., August 1, 2008; 28(15): 4875 - 4882.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. V. Semenov, X. Zhang, and X. He
DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation
J. Biol. Chem., August 1, 2008; 283(31): 21427 - 21432.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. T. MacDonald, C. Yokota, K. Tamai, X. Zeng, and X. He
Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6
J. Biol. Chem., June 6, 2008; 283(23): 16115 - 16123.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C.-H. Xia, H. Liu, D. Cheung, M. Wang, C. Cheng, X. Du, B. Chang, B. Beutler, and X. Gong
A model for familial exudative vitreoretinopathy caused by LPR5 mutations
Hum. Mol. Genet., June 1, 2008; 17(11): 1605 - 1612.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
K.-A. Kim, M. Wagle, K. Tran, X. Zhan, M. A. Dixon, S. Liu, D. Gros, W. Korver, S. Yonkovich, N. Tomasevic, et al.
R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism
Mol. Biol. Cell, June 1, 2008; 19(6): 2588 - 2596.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Zhang, K. Cho, Y. Huang, J. P. Lyons, X. Zhou, K. Sinha, P. D. McCrea, and B. de Crombrugghe
Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix
PNAS, May 13, 2008; 105(19): 6936 - 6941.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. H. Magdesian, M. M. V. F. Carvalho, F. A. Mendes, L. M. Saraiva, M. A. Juliano, L. Juliano, J. Garcia-Abreu, and S. T. Ferreira
Amyloid-{beta} Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/{beta}-Catenin Signaling
J. Biol. Chem., April 4, 2008; 283(14): 9359 - 9368.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. M. Wolf, A. I. Lyuksyutova, A. G. Fenstermaker, B. Shafer, C. G. Lo, and Y. Zou
Phosphatidylinositol-3-Kinase-Atypical Protein Kinase C Signaling Is Required for Wnt Attraction and Anterior-Posterior Axon Guidance
J. Neurosci., March 26, 2008; 28(13): 3456 - 3467.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Kruger, I. Kratchmarova, B. Blagoev, Y.-H. Tseng, C. R. Kahn, and M. Mann
Dissection of the insulin signaling pathway via quantitative phosphoproteomics
PNAS, February 19, 2008; 105(7): 2451 - 2456.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X. Zeng, H. Huang, K. Tamai, X. Zhang, Y. Harada, C. Yokota, K. Almeida, J. Wang, B. Doble, J. Woodgett, et al.
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions
Development, January 15, 2008; 135(2): 367 - 375.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Hassler, C.-M. Cruciat, Y.-L. Huang, S. Kuriyama, R. Mayor, and C. Niehrs
Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling
Development, December 1, 2007; 134(23): 4255 - 4263.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. C. Manolagas and M. Almeida
Gone with the Wnts: {beta}-Catenin, T-Cell Factor, Forkhead Box O, and Oxidative Stress in Age-Dependent Diseases of Bone, Lipid, and Glucose Metabolism
Mol. Endocrinol., November 1, 2007; 21(11): 2605 - 2614.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Z. Khan, S. Vijayakumar, T. V. de la Torre, S. Rotolo, and A. Bafico
Analysis of Endogenous LRP6 Function Reveals a Novel Feedback Mechanism by Which Wnt Negatively Regulates Its Receptor
Mol. Cell. Biol., October 15, 2007; 27(20): 7291 - 7301.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Y. Sokol and K. A. Wharton Jr
WNTers in La Jolla
Development, October 1, 2007; 134(19): 3393 - 3399.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. E. Willnow, A. Hammes, and S. Eaton
Lipoproteins and their receptors in embryonic development: more than cholesterol clearance
Development, September 15, 2007; 134(18): 3239 - 3249.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. E. Binnerts, K.-A. Kim, J. M. Bright, S. M. Patel, K. Tran, M. Zhou, J. M. Leung, Y. Liu, W. E. Lomas III, M. Dixon, et al.
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
PNAS, September 11, 2007; 104(37): 14700 - 14705.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. M. Iglesias, P.-A. Hueber, L. Chu, R. Campbell, A.-M. Patenaude, A. J. Dziarmaga, J. Quinlan, O. Mohamed, D. Dufort, and P. R. Goodyer
Canonical WNT signaling during kidney development
Am J Physiol Renal Physiol, August 1, 2007; 293(2): F494 - F500.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. J. Armstrong, M. Muzylak, A. Sunters, G. Zaman, L. K. Saxon, J. S. Price, and L. E. Lanyon
Wnt/beta-Catenin Signaling Is a Component of Osteoblastic Bone Cell Early Responses to Load-bearing and Requires Estrogen Receptor {alpha}
J. Biol. Chem., July 13, 2007; 282(28): 20715 - 20727.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. Bilic, Y.-L. Huang, G. Davidson, T. Zimmermann, C.-M. Cruciat, M. Bienz, and C. Niehrs
Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
Science, June 15, 2007; 316(5831): 1619 - 1622.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. V. De Ferrari, A. Papassotiropoulos, T. Biechele, F. Wavrant De-Vrieze, M. E. Avila, M. B. Major, A. Myers, K. Saez, J. P. Henriquez, A. Zhao, et al.
Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease
PNAS, May 29, 2007; 104(22): 9434 - 9439.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. Wei, C. Yokota, M. V. Semenov, B. Doble, J. Woodgett, and X. He
R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and beta-Catenin Signaling
J. Biol. Chem., May 25, 2007; 282(21): 15903 - 15911.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Song, K. R. Schwab, L. T. Patterson, T. Yamaguchi, X. Lin, S. S. Potter, and R. A. Lang
pygopus 2 has a crucial, Wnt pathway-independent function in lens induction
Development, May 15, 2007; 134(10): 1873 - 1885.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
T. Benzing, M. Simons, and G. Walz
Wnt Signaling in Polycystic Kidney Disease
J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1389 - 1398.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. Kurumada, A. Onishi, H. Imai, K. Ishii, T. Kobayashi, and S. B. Sato
Stage-Specific Association of Apolipoprotein A-I and E in Developing Mouse Retina
Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1815 - 1823.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
H. Komekado, H. Yamamoto, T. Chiba, and A. Kikuchi
Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a
Genes Cells, April 1, 2007; 12(4): 521 - 534.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
A. Kikuchi and H. Yamamoto
Regulation of Wnt Signalling by Receptor-mediated Endocytosis
J. Biochem., April 1, 2007; 141(4): 443 - 451.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. Mani, J. Radhakrishnan, H. Wang, A. Mani, M.-A. Mani, C. Nelson-Williams, K. S. Carew, S. Mane, H. Najmabadi, D. Wu, et al.
LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors
Science, March 2, 2007; 315(5816): 1278 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 IBMS BoneKEyHome page
P. V. Bodine
Wnt Signaling in Bone
IBMS BoneKEy, March 1, 2007; 4(3): 108 - 123.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Coudreuse and H. C. Korswagen
The making of Wnt: new insights into Wnt maturation, sorting and secretion
Development, January 1, 2007; 134(1): 3 - 12.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. V. Semenov and X. He
LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST
J. Biol. Chem., December 15, 2006; 281(50): 38276 - 38284.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. D. Weatherbee, K. V. Anderson, and L. A. Niswander
LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction.
Development, December 1, 2006; 133(24): 4993 - 5000.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Kurayoshi, N. Oue, H. Yamamoto, M. Kishida, A. Inoue, T. Asahara, W. Yasui, and A. Kikuchi
Expression of Wnt-5a Is Correlated with Aggressiveness of Gastric Cancer by Stimulating Cell Migration and Invasion
Cancer Res., November 1, 2006; 66(21): 10439 - 10448.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Sato, D. K. Khadka, W. Liu, R. Bharti, L. W. Runnels, I. B. Dawid, and R. Habas
Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation
Development, November 1, 2006; 133(21): 4219 - 4231.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Sawakami, A. G. Robling, M. Ai, N. D. Pitner, D. Liu, S. J. Warden, J. Li, P. Maye, D. W. Rowe, R. L. Duncan, et al.
The Wnt Co-receptor LRP5 Is Essential for Skeletal Mechanotransduction but Not for the Anabolic Bone Response to Parathyroid Hormone Treatment
J. Biol. Chem., August 18, 2006; 281(33): 23698 - 23711.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X. He and J. D. Axelrod
A WNTer wonderland in Snowbird.
Development, July 1, 2006; 133(14): 2597 - 2603.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Mukhopadhyay, M. Gorivodsky, S. Shtrom, A. Grinberg, C. Niehrs, M. I. Morasso, and H. Westphal
Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium
Development, June 1, 2006; 133(11): 2149 - 2154.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-S. Nam, T. J. Turcotte, P. F. Smith, S. Choi, and J. K. Yoon
Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate beta-Catenin-dependent Gene Expression
J. Biol. Chem., May 12, 2006; 281(19): 13247 - 13257.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Torban, A. Dziarmaga, D. Iglesias, L. L. Chu, T. Vassilieva, M. Little, M. Eccles, M. Discenza, J. Pelletier, and P. Goodyer
PAX2 Activates WNT4 Expression during Mammalian Kidney Development
J. Biol. Chem., May 5, 2006; 281(18): 12705 - 12712.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Swiatek, H. Kang, B. A. Garcia, J. Shabanowitz, G. S. Coombs, D. F. Hunt, and D. M. Virshup
Negative Regulation of LRP6 Function by Casein Kinase I {epsilon} Phosphorylation
J. Biol. Chem., May 5, 2006; 281(18): 12233 - 12241.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Wang, N. S. Hamblet, S. Mark, M. E. Dickinson, B. C. Brinkman, N. Segil, S. E. Fraser, P. Chen, J. B. Wallingford, and A. Wynshaw-Boris
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
Development, May 1, 2006; 133(9): 1767 - 1778.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Gustafson and U. Smith
Cytokines Promote Wnt Signaling and Inflammation and Impair the Normal Differentiation and Lipid Accumulation in 3T3-L1 Preadipocytes
J. Biol. Chem., April 7, 2006; 281(14): 9507 - 9516.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Pollheimer, T. Loregger, S. Sonderegger, L. Saleh, S. Bauer, M. Bilban, K. Czerwenka, P. Husslein, and M. Knofler
Activation of the Canonical Wingless/T-Cell Factor Signaling Pathway Promotes Invasive Differentiation of Human Trophoblast
Am. J. Pathol., April 1, 2006; 168(4): 1134 - 1147.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. T. Struewing, A. Toborek, and C. D. Mao
Mitochondrial and Nuclear Forms of Wnt13 Are Generated via Alternative Promoters, Alternative RNA Splicing, and Alternative Translation Start Sites
J. Biol. Chem., March 17, 2006; 281(11): 7282 - 7293.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
H. Jian, X. Shen, I. Liu, M. Semenov, X. He, and X.-F. Wang
Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells.
Genes & Dev., March 15, 2006; 20(6): 666 - 674.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-J. Boucher, L. Selander, L. Carlsson, and H. Edlund
Phosphorylation Marks IPF1/PDX1 Protein for Degradation by Glycogen Synthase Kinase 3-dependent Mechanisms
J. Biol. Chem., March 10, 2006; 281(10): 6395 - 6403.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. A. Price
CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling.
Genes & Dev., February 15, 2006; 20(4): 399 - 410.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
K. M. Cadigan and Y. I. Liu
Wnt signaling: complexity at the surface
J. Cell Sci., February 1, 2006; 119(3): 395 - 402.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Croce, L. Duloquin, G. Lhomond, D. R. McClay, and C. Gache
Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development
Development, February 1, 2006; 133(3): 547 - 557.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Almeida, L. Han, T. Bellido, S. C. Manolagas, and S. Kousteni
Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by {beta}-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT
J. Biol. Chem., December 16, 2005; 280(50): 41342 - 41351.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Piddini, F. Marshall, L. Dubois, E. Hirst, and J.-P. Vincent
Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs
Development, December 15, 2005; 132(24): 5479 - 5489.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. D. Castellone, H. Teramoto, B. O. Williams, K. M. Druey, and J. S. Gutkind
Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-{beta}-Catenin Signaling Axis
Science, December 2, 2005; 310(5753): 1504 - 1510.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
L. Muzio, J.M. Soria, M. Pannese, S. Piccolo, and A. Mallamaci
A Mutually Stimulating Loop Involving Emx2 and Canonical Wnt Signalling Specifically Promotes Expansion of Occipital Cortex and Hippocampus
Cereb Cortex, December 1, 2005; 15(12): 2021 - 2028.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
Y. Li, J. Chen, W. Lu, L. M. McCormick, J. Wang, and G. Bu
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
J. Cell Sci., November 15, 2005; 118(22): 5305 - 5314.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S.-i. Hino, C. Tanji, K. I. Nakayama, and A. Kikuchi
Phosphorylation of {beta}-Catenin by Cyclic AMP-Dependent Protein Kinase Stabilizes {beta}-Catenin through Inhibition of Its Ubiquitination
Mol. Cell. Biol., October 15, 2005; 25(20): 9063 - 9072.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. B. Wallingford and R. Habas
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Development, October 15, 2005; 132(20): 4421 - 4436.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Carter, X. Chen, B. Slowinska, S. Minnerath, S. Glickstein, L. Shi, F. Campagne, H. Weinstein, and M. E. Ross
Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6
PNAS, September 6, 2005; 102(36): 12843 - 12848.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
R. Takada, H. Hijikata, H. Kondoh, and S. Takada
Analysis of combinatorial effects of Wnts and Frizzleds on {beta}-catenin/armadillo stabilization and Dishevelled phosphorylation
Genes Cells, September 1, 2005; 10(9): 919 - 928.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y.-W. Qiang, K. Walsh, L. Yao, N. Kedei, P. M. Blumberg, J. S. Rubin, J. Shaughnessy Jr, and S. Rudikoff
Wnts induce migration and invasion of myeloma plasma cells
Blood, September 1, 2005; 106(5): 1786 - 1793.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
D. Hamerman
Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies
QJM, July 1, 2005; 98(7): 467 - 484.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Ai, S. L. Holmen, W. Van Hul, B. O. Williams, and M. L. Warman
Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling
Mol. Cell. Biol., June 15, 2005; 25(12): 4946 - 4955.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. L. Holmen, C. R. Zylstra, A. Mukherjee, R. E. Sigler, M.-C. Faugere, M. L. Bouxsein, L. Deng, T. L. Clemens, and B. O. Williams
Essential Role of {beta}-Catenin in Postnatal Bone Acquisition
J. Biol. Chem., June 3, 2005; 280(22): 21162 - 21168.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Li, Y. Zhang, H. Kang, W. Liu, P. Liu, J. Zhang, S. E. Harris, and D. Wu
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
J. Biol. Chem., May 20, 2005; 280(20): 19883 - 19887.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Charron and M. Tessier-Lavigne
Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance
Development, May 15, 2005; 132(10): 2251 - 2262.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
G. Liu, A. Bafico, and S. A. Aaronson
The Mechanism of Endogenous Receptor Activation Functionally Distinguishes Prototype Canonical and Noncanonical Wnts
Mol. Cell. Biol., May 1, 2005; 25(9): 3475 - 3482.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. M. Krane
Identifying genes that regulate bone remodeling as potential therapeutic targets
J. Exp. Med., March 21, 2005; 201(6): 841 - 843.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Garnis, J. Campbell, J. J. Davies, C. MacAulay, S. Lam, and W. L. Lam
Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis
Hum. Mol. Genet., February 15, 2005; 14(4): 475 - 482.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Han, D. Yan, T. Y. Belenkaya, and X. Lin
Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc
Development, February 15, 2005; 132(4): 667 - 679.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Kapsimali, L. Caneparo, C. Houart, and S. W. Wilson
Inhibition of Wnt/Axin/{beta}-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity
Development, December 1, 2004; 131(23): 5923 - 5933.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. Wang, N. Adhikari, Q. Li, and J. L. Hall
LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells
Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2376 - H2383.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C.-m. Chen, W. Strapps, A. Tomlinson, and G. Struhl
Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless
PNAS, November 9, 2004; 101(45): 15961 - 15966.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Kokubu, U. Heinzmann, T. Kokubu, N. Sakai, T. Kubota, M. Kawai, M. B. Wahl, J. Galceran, R. Grosschedl, K. Ozono, et al.
Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis
Development, November 1, 2004; 131(21): 5469 - 5480.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Kawakami, C. R. Esteban, T. Matsui, J. Rodriguez-Leon, S. Kato, and J. C. I. Belmonte
Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos
Development, October 1, 2004; 131(19): 4763 - 4774.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
L. Lum and P. A. Beachy
The Hedgehog Response Network: Sensors, Switches, and Routers
Science, June 18, 2004; 304(5678): 1755 - 1759.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
O. G. Kelly, K. I. Pinson, and W. C. Skarnes
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
Development, June 15, 2004; 131(12): 2803 - 2815.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004