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First published online 17 March 2004
doi: 10.1242/dev.01079
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1 Laboratory for Cell Culture Development, RIKEN Brain Science Institute,
Saitama 351-0198, Japan
2 Molecular Neuropathology Group, RIKEN Brain Science Institute, Saitama
351-0198, Japan
3 Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Saitama
351-0198, Japan
4 Division of Gene Function in Animals, Nara Institute of Science and
Technology, Nara 630-0192, Japan
5 Immune System Development Group, RIKEN Research Center for Allergy and
Immunology, Kanagawa 230-0045, Japan
6 Laboratory of Reproductive and Developmental Toxicology, National Institute of
Environmental Health Sciences, Research Triangle Park, NC 27709, USA
* Author for correspondence (e-mail: masahisa{at}brain.riken.go.jp)
Accepted 7 January 2004
Interactions between ectodermal and mesenchymal extracellular signaling pathways regulate hair follicle (HF) morphogenesis and hair cycling. Bone morphogenetic proteins (BMPs) are known to be important in hair follicle development by affecting the local cell fate modulation. To study the role of BMP signaling in the HF, we disrupted Bmpr1a, which encodes the BMP receptor type IA (BMPR1A) in an HF cell-specific manner, using the Cre/loxP system. We found that the differentiation of inner root sheath, but not outer root sheath, was severely impaired in mutant mice. The number of HFs was reduced in the dermis and subcutaneous tissue, and cycling epithelial cells were reduced in mutant mice HFs. Our results strongly suggest that BMPR1A signaling is essential for inner root sheath differentiation and is indispensable for HF renewal in adult skin.
Key words: Bone morphogenetic protein, Type I receptor, Hair follicle cycling, Mouse
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