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First published online 31 March 2004
doi: 10.1242/dev.01083

Development 131, 1903-1912 (2004)
Published by The Company of Biologists 2004
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Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling

Dhanisha Jhaveri1, Sumiti Saharan1, Anindya Sen1 and Veronica Rodrigues1,2,*

1 Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India
2 National Centre for Biological Sciences, TIFR, GKVK PO, Bangalore 560065, India

* Author for correspondence (e-mail: veronica{at}tifr.res.in)

Accepted 20 January 2003

Olfactory receptor neurons and the interneurons of the olfactory lobe are organized in distinct units called glomeruli. We have used expression patterns and genetic analysis to demonstrate that a combinatorial code of Roundabout (Robo) receptors act to position sensory terminals within the olfactory lobe. Groups of sensory neurons possess distinct blends of Robo and Robo3 and disruption of levels by loss-of-function or ectopic expression results in aberrant targeting. In the wild type, most of the neurons send collateral branches to the contralateral lobe. Our data suggests that guidance of axons across brain hemispheres is mediated by Slit-dependent Robo2 signaling. The location of sensory arbors at distinct positions within the lobe allows short-range interactions with projection neurons leading to formation of the glomeruli.

Key words: Olfactory lobe, Sensory neurons, Robo receptors, Slit, Glomerular patterning


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Development 2004 131: e901. [Full Text]  



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© The Company of Biologists Ltd 2004