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First published online 31 March 2004
doi: 10.1242/dev.01088

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The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos

Kathryn Good^1,2,*, Rafal Ciosk^1,2,*, Jeremy Nance^1,2,*, Alexandre Neves^1,2, Russell J. Hill^1,2,3 and James R. Priess^1,2,4,

¹ Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
² Howard Hughes Medical Institute, Seattle, WA 98109, USA
³ Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
⁴ Department of Zoology, University of Washington, Seattle, WA 98195, USA

Author for correspondence (e-mail: jpriess{at}fhcrc.org)

Accepted 22 January 2004

The four-cell C. elegans embryo contains two sister cells called ABa and ABp that initially have equivalent abilities to produce ectodermal cell types. Multiple Notch-mediated interactions occur during the early cell divisions that diversify the ABa and ABp descendants. The first interaction determines the pattern of ectodermal cell types produced by ABp. The second interaction induces two ABa granddaughters to become mesodermal precursors. We show that T-box transcription factors called TBX-37 and TBX-38 are essential for mesodermal induction, and that these factors are expressed in ABa, but not ABp, descendants. We provide evidence that the first Notch interaction functions largely, if not entirely, to prevent TBX-37, TBX-38 expression in ABp descendants. Neither the second Notch interaction nor TBX-37, TBX-38 alone are sufficient for mesodermal induction, indicating that both must function together. We conclude that TBX-37, TBX-38 play a key role in distinguishing the outcomes of two sequential Notch-mediated interactions.

Key words: C. elegans, GLP-1, Notch, T-box, Mesoderm, Induction

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