spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online April 22, 2004
doi: 10.1242/10.1242/dev.01122

Development 131, 2149-2159 (2004)
Published by The Company of Biologists 2004
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bulgakov, O. V.
Right arrow Articles by Li, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bulgakov, O. V.
Right arrow Articles by Li, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues

Oleg V. Bulgakov1,*, Jonathan T. Eggenschwiler2,*,{dagger}, Dong-Hyun Hong1, Kathryn V. Anderson2 and Tiansen Li1,{ddagger}

1 The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
2 Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA

{ddagger} Author for correspondence (e-mail: tli{at}meei.harvard.edu)

Accepted 27 January 2004

Sonic hedgehog (SHH) is a secreted morphogen that regulates the patterning and growth of many tissues in the developing mouse embryo, including the central nervous system (CNS). We show that a member of the FK506-binding protein family, FKBP8, is an essential antagonist of SHH signaling in CNS development. Loss of FKBP8 causes ectopic and ligand-independent activation of the Shh pathway, leading to expansion of ventral cell fates in the posterior neural tube and suppression of eye development. Although it is expressed broadly, FKBP8 is required to antagonize SHH signaling primarily in neural tissues, suggesting that hedgehog signal transduction is subject to cell-type specific modulation during mammalian development.

Key words: FKBP8, FKBP38, Sonic hedgehog, Neural tube patterning, Signaling, Mouse


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
S. Barth, F. Edlich, U. Berchner-Pfannschmidt, S. Gneuss, G. Jahreis, P. A. Hasgall, J. Fandrey, R. H. Wenger, and G. Camenisch
Hypoxia-inducible Factor Prolyl-4-hydroxylase PHD2 Protein Abundance Depends on Integral Membrane Anchoring of FKBP38
J. Biol. Chem., August 21, 2009; 284(34): 23046 - 23058.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
V. L. Patterson, C. Damrau, A. Paudyal, B. Reeve, D. T. Grimes, M. E. Stewart, D. J. Williams, P. Siggers, A. Greenfield, and J. N. Murdoch
Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway
Hum. Mol. Genet., May 15, 2009; 18(10): 1719 - 1739.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
R. X. Norman, H. W. Ko, V. Huang, C. M. Eun, L. L. Abler, Z. Zhang, X. Sun, and J. T. Eggenschwiler
Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling
Hum. Mol. Genet., May 15, 2009; 18(10): 1740 - 1754.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
I. F. Tsigelny, V. L. Kouznetsova, D. E. Sweeney, W. Wu, K. T. Bush, and S. K. Nigam
Analysis of Metagene Portraits Reveals Distinct Transitions During Kidney Organogenesis
Sci. Signal., December 9, 2008; 1(49): ra16 - ra16.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. Philipp, G. B. Fralish, A. R. Meloni, W. Chen, A. W. MacInnes, L. S. Barak, and M. G. Caron
Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase
Mol. Biol. Cell, December 1, 2008; 19(12): 5478 - 5489.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
M. Shirane, M. Ogawa, J. Motoyama, and K. I. Nakayama
Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse.
Genes Cells, June 1, 2008; 13(6): 635 - 651.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
Y. Chen, P. Sternberg, and J. Cai
Characterization of a Bcl-XL-Interacting Protein FKBP8 and Its Splice Variant in Human RPE Cells
Invest. Ophthalmol. Vis. Sci., April 1, 2008; 49(4): 1721 - 1727.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
T. Okamoto, H. Omori, Y. Kaname, T. Abe, Y. Nishimura, T. Suzuki, T. Miyamura, T. Yoshimori, K. Moriishi, and Y. Matsuura
A Single-Amino-Acid Mutation in Hepatitis C Virus NS5A Disrupting FKBP8 Interaction Impairs Viral Replication
J. Virol., April 1, 2008; 82(7): 3480 - 3489.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
R. L. Y. Wong, B. J. Wlodarczyk, K. S. Min, M. L. Scott, S. Kartiko, W. Yu, M. Y. Merriweather, P. Vogel, B. P. Zambrowicz, and R. H. Finnell
Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube
Hum. Mol. Genet., February 14, 2008; 17(4): 587 - 601.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Edlich, M. Maestre-Martinez, F. Jarczowski, M. Weiwad, M.-C. Moutty, M. Malesevic, G. Jahreis, G. Fischer, and C. Lucke
A Novel Calmodulin-Ca2+ Target Recognition Activates the Bcl-2 Regulator FKBP38
J. Biol. Chem., December 14, 2007; 282(50): 36496 - 36504.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Edlich, F. Erdmann, F. Jarczowski, M.-C. Moutty, M. Weiwad, and G. Fischer
The Bcl-2 Regulator FKBP38-Calmodulin-Ca2+ Is Inhibited by Hsp90
J. Biol. Chem., May 25, 2007; 282(21): 15341 - 15348.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Saito, S. Williams, A. Bulankina, S. Honing, and T. Mustelin
Association of Protein-tyrosine Phosphatase MEG2 via Its Sec14p Homology Domain with Vesicle-trafficking Proteins
J. Biol. Chem., May 18, 2007; 282(20): 15170 - 15178.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Barth, J. Nesper, P. A. Hasgall, R. Wirthner, K. J. Nytko, F. Edlich, D. M. Katschinski, D. P. Stiehl, R. H. Wenger, and G. Camenisch
The Peptidyl Prolyl cis/trans Isomerase FKBP38 Determines Hypoxia-Inducible Transcription Factor Prolyl-4-Hydroxylase PHD2 Protein Stability
Mol. Cell. Biol., May 15, 2007; 27(10): 3758 - 3768.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Koide, T. Hayata, and K. W. Y. Cho
Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase
Development, June 15, 2006; 133(12): 2395 - 2405.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Huangfu and K. V. Anderson
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
Development, January 1, 2006; 133(1): 3 - 14.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. F. Cooper, K. P. Yu, M. Brueckner, L. L. Brailey, L. Johnson, J. M. McGrath, and A. E. Bale
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
Development, October 1, 2005; 132(19): 4407 - 4417.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang
Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development
Mol. Cell. Biol., August 15, 2005; 25(16): 7042 - 7053.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. Garcia-Garcia, J. T. Eggenschwiler, T. Caspary, H. L. Alcorn, M. R. Wyler, D. Huangfu, A. S. Rakeman, J. D. Lee, E. H. Feinberg, J. R. Timmer, et al.
Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics
PNAS, April 26, 2005; 102(17): 5913 - 5919.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Y. Tay, P. W. Ingham, and S. Roy
A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
Development, February 15, 2005; 132(4): 625 - 634.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
L. Lum and P. A. Beachy
The Hedgehog Response Network: Sensors, Switches, and Routers
Science, June 18, 2004; 304(5678): 1755 - 1759.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004