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First published online December 8, 2004
doi: 10.1242/10.1242/dev.01539
Review |
1 Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
2 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA
02142, USA
Author for correspondence (e-mail:
rebay{at}wi.mit.edu)
SUMMARY
Context-specific integration of information received from the Notch, Transforming growth factor ß, Wingless/Wnt, Hedgehog and Epidermal growth factor receptor signaling pathways sets the stage for deployment of the retinal determination gene network (RDGN), a group of transcription factors that collectively directs the formation of the eye and other tissues. Recent investigations have revealed how these transcription factors are regulated by their interactions with each other and with effectors of the above signaling pathways. Further study of the RDGN may provide insights into how common cues can generate context-specific responses, a key aspect of developmental regulation that remains poorly understood.
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