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First published online April 27, 2005
doi: 10.1242/10.1242/dev.01830

Development 132, 2251-2262 (2005)
Published by The Company of Biologists 2005
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Review

Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance

Frédéric Charron1,* and Marc Tessier-Lavigne1,2,{dagger}

1 Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, California 94305, USA
2 Genentech Incorporated, 1 DNA Way, South San Francisco, California 94080, USA

{dagger} Author for correspondence (e-mail: marctl{at}stanford.edu)

SUMMARY

During embryonic development, morphogens act as graded positional cues to dictate cell fate specification and tissue patterning. Recent findings indicate that morphogen gradients also serve to guide axonal pathfinding during development of the nervous system. These findings challenge our previous notions about morphogens and axon guidance molecules, and suggest that these proteins, rather than having sharply divergent functions, act more globally to provide graded positional information that can be interpreted by responding cells either to specify cell fate or to direct axonal pathfinding. This review presents the roles identified for members of three prominent morphogen families – the Hedgehog, Wnt and TGFß/BMP families – in axon guidance, and discusses potential implications for the molecular mechanisms underlying their guidance functions.


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