spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 13 April 2005
doi: 10.1242/dev.01797

Development 132, 2287-2297 (2005)
Published by The Company of Biologists 2005
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01797v1
132/10/2287    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Audibert, A.
Right arrow Articles by Gho, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Audibert, A.
Right arrow Articles by Gho, M.

Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage

Agnès Audibert, Françoise Simon and Michel Gho*

UMR 7622, CNRS-University Paris VI. 9, Quai Saint Bernard, 75005 Paris, France

* Author for correspondence (e-mail: michel.gho{at}snv.jussieu.fr)

Accepted 18 February 2005

In the Drosophila bristle lineage, five differentiated cells arise from a precursor cell after a rapid sequence of asymmetric cell divisions (one every 2 hours). We show that, in mitotic cells, this rapid cadence of cell divisions is associated with cell cycles essentially devoid of the G1-phase. This feature is due to the expression of Cyclin E that precedes each cell division, and the differential expression of the S-transition negative regulator, Dacapo. Thus, apart from endocycles (G/S), which occurred in two out of five terminal cells, two other cell cycles coexist in this lineage: (1) an atypical cell cycle (S/G2/M), in which the S-phase is initiated during the preceding telophase; and (2) a canonical cell cycle (G1/S/G2/M) with a brief G1 phase. These two types of cell cycle result from either the absence or very transient expression of Dap, respectively. Finally, we show that the fate determinant factor, Tramtrack, downregulates Cyclin E expression and is probably involved in the exit of the cells from the cell cycle.

Key words: BrdU, Dacapo, G1-phase, In vivo, Microchaete, Tramtrack, Drosophila




This article has been cited by other articles:


Home page
 DevelopmentHome page
P.-J. Chang, Y.-L. Hsiao, A.-C. Tien, Y.-C. Li, and H. Pi
Negative-feedback regulation of proneural proteins controls the timing of neural precursor division
Development, September 15, 2008; 135(18): 3021 - 3030.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
J. Sun, L. Smith, A. Armento, and W.-M. Deng
Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling
J. Cell Biol., September 8, 2008; 182(5): 885 - 896.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
W. Chia, W. G. Somers, and H. Wang
Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis
J. Cell Biol., January 28, 2008; 180(2): 267 - 272.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. J. Araujo, C. Cela, and M. Llimargas
Tramtrack regulates different morphogenetic events during Drosophila tracheal development
Development, October 15, 2007; 134(20): 3665 - 3676.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005