|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online 13 April 2005
doi: 10.1242/dev.01819
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AgResearch Crown Research Institute, Ruakura Campus, East Street, Hamilton 2001, New Zealand
Author for correspondence (e-mail:
peter.pfeffer{at}agresearch.co.nz)
Accepted 7 March 2005
The extraembryonic ectoderm (ExE) is essential for mammalian placental formation and survival of the embryo in utero. We have obtained a mouse model lacking the ExE, by targeted deletion of the transcription factor Elf5. Although Elf5 mutant embryos implant and form an ectoplacental cone, no trophoblast stem (TS) cells can be derived, indicating that the absence of ExE is a result of the lack of TS cell maintenance. Embryos without ExE tissue are able to form the anterior visceral endoderm but fail to undergo gastrulation, demonstrating an essential role for the ExE in embryonic patterning during a defined window of development.
Key words: Elf5, Extraembryonic ectoderm, Trophoblast stem cells, AVE, Mesoderm
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Home, S. Ray, D. Dutta, I. Bronshteyn, M. Larson, and S. Paul GATA3 Is Selectively Expressed in the Trophectoderm of Peri-implantation Embryo and Directly Regulates Cdx2 Gene Expression J. Biol. Chem., October 16, 2009; 284(42): 28729 - 28737. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Jedlicka, X. Sui, L. Sussel, and A. Gutierrez-Hartmann Ets Transcription Factors Control Epithelial Maturation and Transit and Crypt-Villus Morphogenesis in the Mammalian Intestine Am. J. Pathol., April 1, 2009; 174(4): 1280 - 1290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Goller, F. Vauti, S. Ramasamy, and H.-H. Arnold Transcriptional Regulator BPTF/FAC1 Is Essential for Trophoblast Differentiation during Early Mouse Development Mol. Cell. Biol., November 15, 2008; 28(22): 6819 - 6827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Oakes, M. J. Naylor, M.-L. Asselin-Labat, K. D. Blazek, M. Gardiner-Garden, H. N. Hilton, M. Kazlauskas, M. A. Pritchard, L. A. Chodosh, P. L. Pfeffer, et al. The Ets transcription factor Elf5 specifies mammary alveolar cell fate Genes & Dev., March 1, 2008; 22(5): 581 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Papadaki, M. Alexiou, G. Cecena, M. Verykokakis, A. Bilitou, J. C. Cross, R. G. Oshima, and G. Mavrothalassitis Transcriptional Repressor Erf Determines Extraembryonic Ectoderm Differentiation Mol. Cell. Biol., July 15, 2007; 27(14): 5201 - 5213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. A. Winger, J. Guttormsen, H. Gavin, and F. Bhushan Heat Shock Protein 1 and the Mitogen-Activated Protein Kinase 14 Pathway Are Important for Mouse Trophoblast Stem Cell Differentiation Biol Reprod, May 1, 2007; 76(5): 884 - 891. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kaji, J. Nichols, and B. Hendrich Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells Development, March 15, 2007; 134(6): 1123 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ozturk, L. J. Donald, L. Li, H. W. Duckworth, and M. L. Duckworth Proteomic Identification of AP2{gamma} as a Rat Placental Lactogen II Trophoblast Cell-Specific Enhancer Binding Protein Endocrinology, September 1, 2006; 147(9): 4319 - 4329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jouneau, Q. Zhou, A. Camus, V. Brochard, L. Maulny, J. Collignon, and J.-P. Renard Developmental abnormalities of NT mouse embryos appear early after implantation. Development, April 1, 2006; 133(8): 1597 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Georgiades and J. Rossant Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development Development, March 15, 2006; 133(6): 1059 - 1068. [Abstract] [Full Text] [PDF]
|
|
