|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online June 1, 2005
doi: 10.1242/10.1242/dev.01858
1 Program in Developmental Biology, Baylor College of Medicine, Houston, TX
77030, USA
2 Department of Molecular Genetics, University of Texas, M. D. Anderson Cancer
Center, Houston, TX 77030, USA
3 Department of Molecular and Cellular Biology, Harvard University, Cambridge,
MA 02138, USA
4 Department of Urology, Columbia University, College of Physicians and
Surgeons, New York, NY 10032, USA
* Author for correspondence (e-mail: rrb{at}mdanderson.org)
Accepted 18 April 2005
Kidney organogenesis requires the morphogenesis of epithelial tubules. Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium transitions and tubular morphogenesis to form nephrons, the functional units of the kidney. The LIM-class homeobox gene Lim1 is expressed in the intermediate mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates and their derivatives. Lim1-null mice lack kidneys because of a failure of nephric duct formation, precluding studies of the role of Lim1 at later stages of kidney development. Here, we show that Lim1 functions in distinct tissue compartments of the developing metanephros for both proper development of the ureteric buds and the patterning of renal vesicles for nephron formation. These observations suggest that Lim1 has essential roles in multiple steps of epithelial tubular morphogenesis during kidney organogenesis. We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Müllerian duct, the anlage of the female reproductive tract.
Key words: Lhx1, Lim1, Mesonephros, Metanephros, Müllerian duct
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
Related articles in Development:
This article has been cited by other articles:
|
|
 |
|
  R. Agrawal, U. Tran, and O. Wessely The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1 Development, December 1, 2009; 136(23): 3927 - 3936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, G. Mernaugh, D.-H. Yang, L. Gewin, M. B. Srichai, R. C. Harris, J. M. Iturregui, R. D. Nelson, D. E. Kohan, D. Abrahamson, et al. {beta}1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity Development, October 1, 2009; 136(19): 3357 - 3366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Raile, E. Klopocki, M. Holder, T. Wessel, A. Galler, D. Deiss, D. Muller, T. Riebel, D. Horn, M. Maringa, et al. Expanded Clinical Spectrum in Hepatocyte Nuclear Factor 1B-Maturity-Onset Diabetes of the Young J. Clin. Endocrinol. Metab., July 1, 2009; 94(7): 2658 - 2664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yu, T. J. Carroll, J. Rajagopal, A. Kobayashi, Q. Ren, and A. P. McMahon A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney Development, January 1, 2009; 136(1): 161 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. El-Dahr, K. Aboudehen, and Z. Saifudeen Transcriptional control of terminal nephron differentiation Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1273 - F1278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Poche, K. M. Kwan, M. A. Raven, Y. Furuta, B. E. Reese, and R. R. Behringer Lim1 Is Essential for the Correct Laminar Positioning of Retinal Horizontal Cells J. Neurosci., December 19, 2007; 27(51): 14099 - 14107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Viana, E. Batourina, H. Huang, G. R. Dressler, A. Kobayashi, R. R. Behringer, E. Shapiro, T. Hensle, S. Lambert, and C. Mendelsohn The development of the bladder trigone, the center of the anti-reflux mechanism Development, October 15, 2007; 134(20): 3763 - 3769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Reggiani, D. Raciti, R. Airik, A. Kispert, and A. W. Brandli The prepattern transcription factor Irx3 directs nephron segment identity Genes & Dev., September 15, 2007; 21(18): 2358 - 2370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Schmidt-Ott, T. N. H. Masckauchan, X. Chen, B. J. Hirsh, A. Sarkar, J. Yang, N. Paragas, V. A. Wallace, D. Dufort, P. Pavlidis, et al. {beta}-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors Development, September 1, 2007; 134(17): 3177 - 3190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhao, K.-M. Kwan, C. M. Mailloux, W.-K. Lee, A. Grinberg, W. Wurst, R. R. Behringer, and H. Westphal LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum PNAS, August 7, 2007; 104(32): 13182 - 13186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kopan, H.-T. Cheng, and K. Surendran Molecular Insights into Segmentation along the Proximal Distal Axis of the Nephron J. Am. Soc. Nephrol., July 1, 2007; 18(7): 2014 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-S. Park, M. T. Valerius, and A. P. McMahon Wnt/{beta}-catenin signaling regulates nephron induction during mouse kidney development Development, July 1, 2007; 134(13): 2533 - 2539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Iizuka-Kogo, T. Ishidao, T. Akiyama, and T. Senda Abnormal development of urogenital organs in Dlgh1-deficient mice Development, May 1, 2007; 134(9): 1799 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Narlis, D. Grote, Y. Gaitan, S. K. Boualia, and M. Bouchard Pax2 and Pax8 Regulate Branching Morphogenesis and Nephron Differentiation in the Developing Kidney J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1121 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kuure, A. Popsueva, M. Jakobson, K. Sainio, and H. Sariola Glycogen Synthase Kinase-3 Inactivation and Stabilization of beta-Catenin Induce Nephron Differentiation in Isolated Mouse and Rat Kidney Mesenchymes J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1130 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-T. Cheng, M. Kim, M. T. Valerius, K. Surendran, K. Schuster-Gossler, A. Gossler, A. P. McMahon, and R. Kopan Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron Development, February 15, 2007; 134(4): 801 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pillai, A. Mansouri, R. Behringer, H. Westphal, and M. Goulding Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord Development, January 15, 2007; 134(2): 357 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Wilhelm, S. Palmer, and P. Koopman Sex Determination and Gonadal Development in Mammals Physiol Rev, January 1, 2007; 87(1): 1 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. James, C. N. Kamei, Q. Wang, R. Jiang, and T. M. Schultheiss Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells Development, August 1, 2006; 133(15): 2995 - 3004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Boyle and M. de Caestecker Role of transcriptional networks in coordinating early events during kidney development Am J Physiol Renal Physiol, July 1, 2006; 291(1): F1 - F8. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O. Perantoni, O. Timofeeva, F. Naillat, C. Richman, S. Pajni-Underwood, C. Wilson, S. Vainio, L. F. Dove, and M. Lewandoski Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development Development, September 1, 2005; 132(17): 3859 - 3871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Grieshammer, C. Cebrian, R. Ilagan, E. Meyers, D. Herzlinger, and G. R. Martin FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons Development, September 1, 2005; 132(17): 3847 - 3857. [Abstract] [Full Text] [PDF]
|
|
