spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online June 1, 2005
doi: 10.1242/10.1242/dev.01848

Development 132, 2907-2916 (2005)
Published by The Company of Biologists 2005
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Broun, M.
Right arrow Articles by Bode, H. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Broun, M.
Right arrow Articles by Bode, H. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Formation of the head organizer in hydra involves the canonical Wnt pathway

Mariya Broun, Lydia Gee, Beate Reinhardt and Hans R. Bode*

Department of Developmental and Cell Biology and the Developmental Biology Center, University of California, Irvine, CA 92697, USA

* Author for correspondence (e-mail: hrbode{at}uci.edu)

Accepted 4 April 2005

Stabilization of ß-catenin by inhibiting the activity of glycogen synthase kinase-3ß has been shown to initiate axis formation or axial patterning processes in many bilaterians. In hydra, the head organizer is located in the hypostome, the apical portion of the head. Treatment of hydra with alsterpaullone, a specific inhibitor of glycogen synthase kinase-3ß, results in the body column acquiring characteristics of the head organizer, as measured by transplantation experiments, and by the expression of genes associated with the head organizer. Hence, the role of the canonical Wnt pathway for the initiation of axis formation was established early in metazoan evolution.

Key words: Hydra, Head organizer, Canonical Wnt pathway


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in Development:

An ancient organizer of axis formation

Development 2005 132: e1205. [Full Text]  

An ancient organizer of axis formation

Development 2005 132: e1205. [Full Text]  



This article has been cited by other articles:


Home page
 Cold Spring Harb Symp Quant BiolHome page
G.S. Richards and B.M. Degnan
The Dawn of Developmental Signaling in the Metazoa
Cold Spring Harb Symp Quant Biol, November 10, 2009; (2009) sqb.2009.74.028v1.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. P. Petersen and P. W. Reddien
A wound-induced Wnt expression program controls planarian regeneration polarity
PNAS, October 6, 2009; 106(40): 17061 - 17066.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb. Perspect. Biol.Home page
H. R. Bode
Axial Patterning in Hydra
Cold Spring Harb Perspect Biol, July 1, 2009; 1(1): a000463 - a000463.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
T. S. Stappenbeck and H. Miyoshi
The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair
Science, June 26, 2009; 324(5935): 1666 - 1669.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Philipp, R. Aufschnaiter, S. Ozbek, S. Pontasch, M. Jenewein, H. Watanabe, F. Rentzsch, T. W. Holstein, and B. Hobmayer
From the Cover: Wnt/{beta}-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra
PNAS, March 17, 2009; 106(11): 4290 - 4295.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Momose, R. Derelle, and E. Houliston
A maternally localised Wnt ligand required for axial patterning in the cnidarian Clytia hemisphaerica
Development, June 15, 2008; 135(12): 2105 - 2113.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C. P. Petersen and P. W. Reddien
Smed-{beta}catenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration
Science, January 18, 2008; 319(5861): 327 - 330.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Bielen, S. Oberleitner, S. Marcellini, L. Gee, P. Lemaire, H. R. Bode, R. Rupp, and U. Technau
Divergent functions of two ancient Hydra Brachyury paralogues suggest specific roles for their C-terminal domains in tissue fate induction
Development, December 1, 2007; 134(23): 4187 - 4197.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Guder, S. Pinho, T. G. Nacak, H. A. Schmidt, B. Hobmayer, C. Niehrs, and T. W. Holstein
An ancient Wnt-Dickkopf antagonism in Hydra
Development, March 1, 2006; 133(5): 901 - 911.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005