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First published online June 27, 2005
doi: 10.1242/10.1242/dev.01907
Review |
Instituto de Neurociencias de Alicante CSIC-UMH, Apartado 18, Sant Joan d'Alacant, 03550, Spain
* Author for correspondence (e-mail: anieto{at}umh.es)
SUMMARY
The functions of the Snail family of zinc-finger transcription factors are essential during embryonic development. One of their best-known functions is to induce epithelial to mesenchymal transitions (EMTs), which convert epithelial cells into migratory mesenchymal cells. In recent years, many orthologues of the Snail family have been identified throughout the animal kingdom, and their study is providing new clues about the EMT-dependent and -independent functions of Snail proteins. Here, we discuss these functions and how they influence cell behaviour during development and during diseases such as metastatic cancer. From these findings, we propose that Snail genes act primarily as survival factors and inducers of cell movement, rather than as inducers of EMT or cell fate.
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D. Sakai, T. Suzuki, N. Osumi, and Y. Wakamatsu Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development Development, April 1, 2006; 133(7): 1323 - 1333. [Abstract] [Full Text] [PDF] |
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J. M. Lee, S. Dedhar, R. Kalluri, and E. W. Thompson The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J. Cell Biol., March 27, 2006; 172(7): 973 - 981. [Abstract] [Full Text] [PDF] |
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M. H. M. Sailer, T. G. Hazel, D. M. Panchision, D. J. Hoeppner, M. E. Schwab, and R. D. G. McKay BMP2 and FGF2 cooperate to induce neural-crest-like fates from fetal and adult CNS stem cells J. Cell Sci., December 15, 2005; 118(24): 5849 - 5860. [Abstract] [Full Text] [PDF] |
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G. Rennebeck, M. Martelli, and N. Kyprianou Anoikis and Survival Connections in the Tumor Microenvironment: Is There a Role in Prostate Cancer Metastasis? Cancer Res., December 15, 2005; 65(24): 11230 - 11235. [Abstract] [Full Text] [PDF] |
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