spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 15 June 2005
doi: 10.1242/dev.01862

Development 132, 3209-3216 (2005)
Published by The Company of Biologists 2005
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrowOA All Versions of this Article:
dev.01862v1
132/14/3209    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Langenberg, T.
Right arrow Articles by Brand, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Langenberg, T.
Right arrow Articles by Brand, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Lineage restriction maintains a stable organizer cell population at the zebrafish midbrain-hindbrain boundary

Tobias Langenberg and Michael Brand*

Department of Genetics, University of Technology, Dresden, c/o Max Planck Institute for Molecular Cell Biology and Genetics, Germany

* Author for correspondence (e-mail: brand{at}mpi-cbg.de)

Accepted 13 May 2005

The vertebrate hindbrain is subdivided into segments, termed neuromeres, that are units of gene expression, cell differentiation and behavior. A key property of such segments is that cells show a restricted ability to mix across segment borders – termed lineage restriction. In order to address segmentation in the midbrain-hindbrain boundary (mhb) region, we have analyzed single cell behavior in the living embryo by acquiring time-lapse movies of the developing mhb region in a transgenic zebrafish line. We traced the movement of hundreds of nuclei, and by matching their position with the expression of a midbrain marker, we demonstrate that midbrain and hindbrain cells arise from two distinct cell populations. Single cell labeling and analysis of the distribution of their progeny shows that lineage restriction is probably established during late gastrulation stages. Our findings suggest that segmentation as an organizing principle in early brain development can be extended to the mhb region. We argue that lineage restriction serves to constrain the position of the mhb organizer cell population.

Key words: Midbrain-hindbrain boundary, Isthmic organizer, Lineage restriction, Neuromeres, segments, Zebrafish, Mesencephalon, Metencephalon, otx2, gbx1, fgf8


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in Development:

Lineage restriction: from fly wing to vertebrate brain

Development 2005 132: e1402. [Full Text]  



This article has been cited by other articles:


Home page
 DevelopmentHome page
S. Scholpp, I. Foucher, N. Staudt, D. Peukert, A. Lumsden, and C. Houart
Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon
Development, September 1, 2007; 134(17): 3167 - 3176.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005