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First published online August 11, 2005
doi: 10.1242/10.1242/dev.01972

Development 132, 3787-3798 (2005)
Published by The Company of Biologists 2005
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Review

Intrinsic and extrinsic regulators of developmental timing: from miRNAs to nutritional cues

Ann E. Rougvie

University of Minnesota, Department of Genetics, Cell Biology and Development, 6-160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA

e-mail: rougvie{at}cbs.umn.edu

SUMMARY

A fundamental challenge in biology is to understand the reproducibility of developmental programs between individuals of the same metazoan species. This developmental precision reflects the meticulous integration of temporal control mechanisms with those that specify other aspects of pattern formation, such as spatial and sexual information. The cues that guide these developmental events are largely intrinsic to the organism but can also include extrinsic inputs, such as nutrition or temperature. This review discusses the well-characterized developmental timing mechanism that patterns the C. elegans epidermis. Components of this pathway are conserved, and their links to developmental time control in other species are considered, including the temporal patterning of the fly nervous system. Particular attention is given to the roles of miRNAs in developmental timing and to the emerging mechanisms that link developmental programs to nutritional cues.




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