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First published online August 11, 2005
doi: 10.1242/10.1242/dev.01961

Development 132, 3895-3905 (2005)
Published by The Company of Biologists 2005
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ß-Catenin-dependent Wnt signalling controls the epithelial organisation of somites through the activation of paraxis

Claudia Linker1,*,{dagger},{ddagger}, Cynthia Lesbros1,*, Jérôme Gros1, Laura W. Burrus2, Alan Rawls3 and Christophe Marcelle1,{ddagger}

1 Laboratoire de Génétique et de Physiologie du Développement (LGPD). Developmental Biology Institute of Marseille (IBDM), CNRS UMR 6545. Université de la Méditerranée, Campus de Luminy, case 907, 13288 Marseille, Cedex 09, France
2 Department of Biology, San Francisco State University, 1600 Holloway Ave., San Francisco, CA 94132, USA
3 School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA

{ddagger} Authors for correspondence (e-mail: c.linker{at}ucl.ac.uk; marcelle{at}ibdm.univ-mrs.fr)

Accepted 30 June 2005

The regulation of cell adhesion in epithelia is a fundamental process governing morphogenesis in embryos and a key step in the progression of invasive cancers. Here, we have analysed the molecular pathways controlling the epithelial organisation of somites. Somites are mesodermal epithelial structures of vertebrate embryos that undergo several changes in cell adhesion during early embryonic life. We show that Wnt6 in the ectoderm overlaying the somites, but not Wnt1 in the neighbouring neural tube, is the most likely candidate molecule responsible for the maintenance of the epithelial structure of the dorsal compartment of the somite: the dermomyotome. We characterised the signalling pathway that mediates Wnt6 activity. Our experiments suggest that the Wnt receptor molecule Frizzled7 probably transduces the Wnt6 signal. Intracellularly, this leads to the activation of the ß-catenin/LEF1-dependent pathway. Finally, we demonstrate that the bHLH transcription factor paraxis, which was previously shown to be a major player in the epithelial organisation of somites, is a target of the ß-catenin signal. We conclude that ß-catenin activity, initiated by Wnt6 and mediated by paraxis, is required for the maintenance of the epithelial structure of somites.

Key words: Chick, Somite, Wnt, Paraxis, ß-Catenin, Epithelial-mesenchymal transition


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