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First published online September 28, 2005
doi: 10.1242/10.1242/dev.02068

Development 132, 4421-4436 (2005)
Published by The Company of Biologists 2005
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Review

The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

John B. Wallingford1 and Raymond Habas2,3

1 Section of Molecular Cell and Developmental Biology, and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
2 Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
3 Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA

e-mail: wallingford{at}mail.utexas.edu and habasra{at}umdnj.edu

SUMMARY

The Dishevelled protein regulates many developmental processes in animals ranging from Hydra to humans. Here, we discuss the various known signaling activities of this enigmatic protein and focus on the biological processes that Dishevelled controls. Through its many signaling activities, Dishevelled plays important roles in the embryo and the adult, ranging from cell-fate specification and cell polarity to social behavior. Dishevelled also has important roles in the governance of polarized cell divisions, in the directed migration of individual cells, and in cardiac development and neuronal structure and function.




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