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First published online October 13, 2005
doi: 10.1242/10.1242/dev.02070


Development 132, 4645-4652 (2005)
Published by The Company of Biologists 2005


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Primer

microPrimer: the biogenesis and function of microRNA

Tingting Du and Phillip D. Zamore*

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA

* Author for correspondence (e-mail: phillip.zamore{at}umassmed.edu)

SUMMARY

Discovered in nematodes in 1993, microRNAs (miRNAs) are non-coding RNAs that are related to small interfering RNAs (siRNAs), the small RNAs that guide RNA interference (RNAi). miRNAs sculpt gene expression profiles during plant and animal development. In fact, miRNAs may regulate as many as one-third of human genes. miRNAs are found only in plants and animals, and in the viruses that infect them. miRNAs function very much like siRNAs, but these two types of small RNAs can be distinguished by their distinct pathways for maturation and by the logic by which they regulate gene expression.


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Cold Spring Harb Symp Quant BiolHome page
C.S. SULLIVAN, A. GRUNDHOFF, S. TEVETHIA, R. TREISMAN, J.M. PIPAS, and D. GANEM
Expression and Function of MicroRNAs in Viruses Great and Small
Cold Spring Harb Symp Quant Biol, January 1, 2006; 71(0): 351 - 356.
[Abstract] [PDF]


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Cold Spring Harb Symp Quant BiolHome page
G.J. HANNON, F.V. RIVAS, E.P. MURCHISON, and J.A. STEITZ
The Expanding Universe of Noncoding RNAs
Cold Spring Harb Symp Quant Biol, January 1, 2006; 71(0): 551 - 564.
[Abstract] [PDF]


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Nucleic Acids ResHome page
S. Davis, B. Lollo, S. Freier, and C. Esau
Improved targeting of miRNA with antisense oligonucleotides.
Nucleic Acids Res., January 1, 2006; 34(8): 2294 - 2304.
[Abstract] [Full Text] [PDF]




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