spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 5 October 2005
doi: 10.1242/dev.02033

Development 132, 4709-4718 (2005)
Published by The Company of Biologists 2005
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02033v1
132/21/4709    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cariboni, A.
Right arrow Articles by Parnavelas, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cariboni, A.
Right arrow Articles by Parnavelas, J. G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons

Anna Cariboni1,2, Sonja Rakic1, Anastasia Liapi1, Roberto Maggi2, Andre Goffinet3 and John G. Parnavelas1,*

1 Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
2 Department of Endocrinology, Centre of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
3 Developmental Neurobiology Unit, University of Louvain Medical School, B1200 Brussels, Belgium

* Author for correspondence (e-mail: j.parnavelas{at}ucl.ac.uk)

Accepted 9 August 2005

Gonadotropin-releasing hormone (GnRH) neurons, a small number of cells scattered in the hypothalamic region of the basal forebrain, play an important role in reproductive function. These cells originate in the olfactory placode and migrate into the basal forebrain in late embryonic life. Here, we show that reelin, which is expressed along the route of the migrating cells, has an inhibitory role in guiding GnRH neurons to the basal forebrain. Only a small (approximately 5%) subpopulation of these neurons expresses one of the reelin receptors (ApoER2/Lrp8), and all GnRH neurons appear to lack the intracellular adaptor protein Dab1, suggesting that the function of reelin is not mediated by the conventional signal transduction pathway. The importance of reelin in the establishment of GnRH neurons in the hypothalamus was confirmed by our finding that the brains of developing and adult reeler mice of both sexes contained a markedly reduced number of these neuroendocrine neurons. Furthermore, the testes of adult males showed dilation of seminiferous tubules and reduction in their density when compared with controls. Mutants lacking the reelin receptors ApoER2 and Vldlr, and scrambler mice lacking Dab1, showed a normal complement of GnRH neurons in the hypothalamus, confirming that the effect of reelin in their migration is independent of Dab1.

Key words: GnRH neurons, Migration, Reelin


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in Development:

Reelin in GnRH neurons

Development 2005 132: e2103. [Full Text]  



This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Tissir, A. Ravni, Y. Achouri, D. Riethmacher, G. Meyer, and A. M. Goffinet
DeltaNp73 regulates neuronal survival in vivo
PNAS, September 29, 2009; 106(39): 16871 - 16876.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
P. Giacobini, A. Messina, F. Morello, N. Ferraris, S. Corso, J. Penachioni, S. Giordano, L. Tamagnone, and A. Fasolo
Semaphorin 4D regulates gonadotropin hormone-releasing hormone-1 neuronal migration through PlexinB1-Met complex
J. Cell Biol., November 3, 2008; 183(3): 555 - 566.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Jossin and A. M. Goffinet
Reelin Signals through Phosphatidylinositol 3-Kinase and Akt To Control Cortical Development and through mTor To Regulate Dendritic Growth
Mol. Cell. Biol., October 15, 2007; 27(20): 7113 - 7124.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Nakano, T. Kohno, T. Hibi, S. Kohno, A. Baba, K. Mikoshiba, K. Nakajima, and M. Hattori
The Extremely Conserved C-terminal Region of Reelin Is Not Necessary for Secretion but Is Required for Efficient Activation of Downstream Signaling
J. Biol. Chem., July 13, 2007; 282(28): 20544 - 20552.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Jossin, L. Gui, and A. M. Goffinet
Processing of Reelin by Embryonic Neurons Is Important for Function in Tissue But Not in Dissociated Cultured Neurons
J. Neurosci., April 18, 2007; 27(16): 4243 - 4252.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Cariboni, J. Hickok, S. Rakic, W. Andrews, R. Maggi, S. Tischkau, and J. G. Parnavelas
Neuropilins and Their Ligands Are Important in the Migration of Gonadotropin-Releasing Hormone Neurons
J. Neurosci., February 28, 2007; 27(9): 2387 - 2395.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Giacobini, A. Messina, S. Wray, C. Giampietro, T. Crepaldi, P. Carmeliet, and A. Fasolo
Hepatocyte Growth Factor Acts as a Motogen and Guidance Signal for Gonadotropin Hormone-Releasing Hormone-1 Neuronal Migration
J. Neurosci., January 10, 2007; 27(2): 431 - 445.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005