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First published online 5 October 2005
doi: 10.1242/dev.02061

Development 132, 4833-4843 (2005)
Published by The Company of Biologists 2005
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Pointed regulates an eye-specific transcriptional enhancer in the Drosophila hedgehog gene, which is required for the movement of the morphogenetic furrow

Edward M. Rogers, Catherine A. Brennan*, Nathan T. Mortimer, Summer Cook, Andrea R. Morris{dagger} and Kevin Moses{ddagger},§

Department of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA

§ Author for correspondence (e-mail: mosesk{at}hhmi.org)

Accepted 24 August 2005

Drosophila development depends on stable boundaries between cellular territories, such as the embryonic parasegment boundaries and the compartment boundaries in the imaginal discs. Patterning in the compound eye is fundamentally different: the boundary is not stable, but moves (the morphogenetic furrow). Paradoxically, Hedgehog signaling is essential to both: Hedgehog is expressed in the posterior compartments in the embryo and in imaginal discs, and posterior to the morphogenetic furrow in the eye. Therefore, uniquely in the eye, cells receiving a Hedgehog signal will eventually produce the same protein. We report that the mechanism that underlies this difference is the special regulation of hedgehog (hh) transcription through the dual regulation of an eye specific enhancer. We show that this enhancer requires the Egfr/Ras pathway transcription factor Pointed. Recently, others have shown that this same enhancer also requires the eye determining transcription factor Sine oculis (So). We discuss these data in terms of a model for a combinatorial code of furrow movement.

Key words: Hedgehog, Pointed, Drosophila, Eye, Morphogenetic furrow, Transcription, Enhancer






© The Company of Biologists Ltd 2005