|
|
|
|||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online October 28, 2005
doi: 10.1242/10.1242/dev.02099
Review |
1 Victor Chang Cardiac Research Institute, St Vincent's Hospital, 384 Victoria
Street, Darlinghurst, New South Wales 2010, Australia
2 Faculties of Medicine and Life Sciences, University of New South Wales,
Kensington, New South Wales 2056, Australia
* Author for correspondence (e-mail: r.harvey{at}victorchang.unsw.edu.au)
SUMMARY
T-box transcription factors are important players in the molecular circuitry that generates lineage diversity and form in the developing embryo. At least seven family members are expressed in the developing mammalian heart, and the human T-box genes TBX1 and TBX5 are mutated in cardiac congenital anomaly syndromes. Here, we review T-box gene function during mammalian heart development in the light of new insights into heart morphogenesis. We see for the first time how hierarchies of transcriptional activation and repression involving multiple T-box factors play out in three-dimensional space to establish the cardiac progenitors fields, to define their subservient lineages, and to generate heart form and function.
This article has been cited by other articles:
![]() |
S. Druyan, J. E. de Oliveira, and C. M. Ashwell Focused Microarrays as a Method to Evaluate Subtle Changes in Gene Expression Poult. Sci., November 1, 2008; 87(11): 2418 - 2429. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. E. Yutzey Teed Off: Cardiac Conduction System Development Requires T-box Transcription Factors Circ. Res., June 6, 2008; 102(11): 1295 - 1297. [Full Text] [PDF] |
||||
![]() |
N. C. Chi, R. M. Shaw, S. De Val, G. Kang, L. Y. Jan, B. L. Black, and D. Y.R. Stainier Foxn4 directly regulates tbx2b expression and atrioventricular canal formation Genes & Dev., March 15, 2008; 22(6): 734 - 739. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Kitamura, T. Takahashi, N. Nakajima, K. Isodono, S. Asada, H. Ueno, T. Ueyama, T. Yoshikawa, H. Matsubara, and H. Oh Stage-Specific Role of Endogenous Smad2 Activation in Cardiomyogenesis of Embryonic Stem Cells Circ. Res., July 6, 2007; 101(1): 78 - 87. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. C. Goetz, D. D. Brown, and F. L. Conlon TBX5 is required for embryonic cardiac cell cycle progression Development, July 1, 2006; 133(13): 2575 - 2584. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. Elliott, M. J. Solloway, N. Wise, C. Biben, M. W. Costa, M. B. Furtado, M. Lange, S. Dunwoodie, and R. P. Harvey A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery Development, April 1, 2006; 133(7): 1311 - 1322. [Abstract] [Full Text] [PDF] |
||||