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First published online 5 January 2005
doi: 10.1242/dev.01600
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1 Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4
7UH, UK
2 Business Unit Bioscience, Plant Research International, PO Box 16, 6700 AA
Wageningen, The Netherlands
* Author for correspondence (e-mail: robert.sablowski{at}bbsrc.ac.uk)
Accepted 25 November 2004
Floral organs, whose identity is determined by specific combinations of homeotic genes, originate from a group of undifferentiated cells called the floral meristem. In Arabidopsis, the homeotic gene AGAMOUS (AG) terminates meristem activity and promotes development of stamens and carpels. To understand the program of gene expression activated by AG, we followed genome-wide expression during early stamen and carpel development. The AG target genes included most genes for which mutant screens revealed a function downstream of AG. Novel targets were validated by in situ hybridisation and binding to AG in vitro and in vivo. Transcription factors formed a large fraction of AG targets, suggesting that during early organogenesis, much of the genetic program is concerned with elaborating gene expression patterns. The results also suggest that AG and other homeotic proteins with which it interacts (SEPALLATA3, APETALA3, PISTILLATA) are coordinately regulated in a positive-feedback loop to maintain their own expression, and that AG activates biosynthesis of gibberellin, which has been proposed to promote the shift from meristem identity to differentiation.
Key words: Homeotic genes, Floral development, Transcription, AGAMOUS
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