|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online 5 January 2005
doi: 10.1242/dev.01592
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Genes and Development Research Group, Hotchkiss Brain Institute, University of Calgary Faculty of Medicine, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
* Author for correspondence (e-mail: weiss{at}ucalgary.ca)
Accepted 23 November 2004
The extrinsic signaling pathways responsible for the formation and maintenance of the unique laminar organization of the forebrain germinal zones are largely unknown. In the present study, we asked whether ciliary neurotrophic factor (CNTF)/leukemia inhibitory factor (LIF)/gp130 signaling plays a role in the development of the germinal layers in the lateral ganglionic eminence. We found that CNTF/LIF/gp130 receptor signaling promotes the self-renewal/expansion of a subpopulation of fibroblast growth factor-responsive ventricular zone (VZ) precursors in the ventral forebrain. Analysis of Lifr-/- mice suggests that CNTF/LIF/gp130 signaling maintains a subpopulation of GSH2+ VZ precursors, which are necessary for normal growth of the early ventral forebrain and for maintaining a gradient of VZ precursor differentiation in the lateral ganglionic eminence, as defined by GSH2, MASH1 and DLX2 expression. Furthermore, addition of exogenous CNTF to embryonic forebrain explant cultures deprived of choroid plexus-derived CNTF, was sufficient to promote a VZ differentiation gradient. In contrast to the forebrain, CNTF/LIF/gp130 signaling reduced, rather than enhanced, precursor self-renewal/expansion in the spinal cord. These results demonstrate a novel region-specific role for CNTF/LIF/gp130 signaling in the development of the germinal layers of the embryonic telencephalon.
Key words: Ventricular zone, Subventricular zone, Self-renewal, Ciliary neurotrophic factor, Leukemia inhibitory factor, Mouse
This article has been cited by other articles:
|
|
 |
|
  R. B. White and M. R. Ziman Genome-wide discovery of Pax7 target genes during development Physiol Genomics, March 10, 2008; 33(1): 41 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. Vaccarino, D. M. Fagel, Y. Ganat, M. E. Maragnoli, L. R. Ment, Y. Ohkubo, M. L. Schwartz, J. Silbereis, and K. M. Smith Astroglial Cells in Development, Regeneration, and Repair Neuroscientist, April 1, 2007; 13(2): 173 - 185. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Bauer and P. H. Patterson Leukemia Inhibitory Factor Promotes Neural Stem Cell Self-Renewal in the Adult Brain. J. Neurosci., November 15, 2006; 26(46): 12089 - 12099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Covey and S. W. Levison Pathophysiology of Perinatal Hypoxia-Ischemia and the Prospects for Repair from Endogenous and Exogenous Stem Cells NeoReviews, July 1, 2006; 7(7): e353 - e362. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshimatsu, D. Kawaguchi, K. Oishi, K. Takeda, S. Akira, N. Masuyama, and Y. Gotoh Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex Development, July 1, 2006; 133(13): 2553 - 2563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Deleyrolle, S. Marchal-Victorion, C. Dromard, V. Fritz, M. Saunier, J.-C. Sabourin, C. Tran Van Ba, A. Privat, and J.-P. Hugnot Exogenous and Fibroblast Growth Factor 2/Epidermal Growth Factor-Regulated Endogenous Cytokines Regulate Neural Precursor Cell Growth and Differentiation Stem Cells, March 1, 2006; 24(3): 748 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.-S. Ge, Q. Dong, C. M. Sottas, V. Papadopoulos, B. R. Zirkin, and M. P. Hardy In search of rat stem Leydig cells: Identification, isolation, and lineage-specific development PNAS, February 21, 2006; 103(8): 2719 - 2724. [Abstract] [Full Text] [PDF]
|
|
