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First published online 19 January 2005
doi: 10.1242/dev.01618

Development 132, 805-816 (2005)
Published by The Company of Biologists 2005
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Lysophosphatidic acid signaling controls cortical actin assembly and cytoarchitecture in Xenopus embryos

Brett Lloyd1,2, QingHua Tao1, Stephanie Lang1 and Chris Wylie1,*

1 Cincinnati Children's Hospital Research Foundation, 3333 Burnett Avenue, Cincinnati, OH 45229, USA
2 PSTP Program, University of Cincinnati College of Medicine, PO Box 670555, Cincinnati, OH 45267, USA

* Author for correspondence (e-mail: christopher.wylie{at}cchmc.org)

Accepted 1 December 2004

The mechanisms that control shape and rigidity of early embryos are not well understood, and yet are required for all embryonic processes to take place. In the Xenopus blastula, the cortical actin network in each blastomere is required for the maintenance of overall embryonic shape and rigidity. However, the mechanism whereby each cell assembles the appropriate pattern and number of actin filament bundles is not known. The existence of a similar network in each blastomere suggests two possibilities: cell-autonomous inheritance of instructions from the egg; or mutual intercellular signaling mediated by cell contact or diffusible signals. We show that intercellular signaling is required for the correct pattern of cortical actin assembly in Xenopus embryos, and that lysophosphatidic acid (LPA) and its receptors, corresponding to LPA1 and LPA2 in mammals, are both necessary and sufficient for this function.

Key words: Lysophosphatidic acid, Actin cytoskeleton, G-protein-coupled receptor, Xenopus


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