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First published online 2 February 2005
doi: 10.1242/dev.01659

Development 132, 1035-1046 (2005)
Published by The Company of Biologists 2005
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The Notch-target gene hairy2a impedes the involution of notochordal cells by promoting floor plate fates in Xenopus embryos

Silvia L. López*, María V. Rosato-Siri*, Paula G. Franco, Alejandra R. Paganelli and Andrés E. Carrasco{dagger}

Laboratorio de Embriología Molecular, Instituto de Biología Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 3° piso (1121), Buenos Aires, Argentina

{dagger} Author for correspondence (e-mail: rqcarras{at}mail.retina.ar)

Accepted 22 December 2004

We have previously shown that the early Xenopus organiser contains cells equally potent to give rise to notochord or floor plate, and that Notch signalling triggers a binary decision, favouring the floor plate fate at the expense of the notochord. Now, we present evidence that Delta1 is the ligand that triggers the binary switch, which is executed through the Notch-mediated activation of hairy2a in the surrounding cells within the organiser, impeding their involution through the blastopore and promoting their incorporation into the hairy2a+ notoplate precursors (future floor-plate cells) in the dorsal non-involuting marginal zone.

Key words: Delta, Notch, Hairy2a, Floor plate, Notochord, Xenopus laevis




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© The Company of Biologists Ltd 2005