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First published online March 24, 2005
doi: 10.1242/10.1242/dev.01789
Review |
CNRS UMR 8542, Ecole Normale Supérieure, 46, rue d'Ulm 75230 Paris cedex, France
* Author for correspondence (e-mail: schweisg{at}wotan.ens.fr)
SUMMARY
Cell-cell signaling is a central process in the formation of multicellular organisms. Notch (N) is the receptor of a conserved signaling pathway that regulates numerous developmental decisions, and the misregulation of N has been linked to various physiological and developmental disorders. The endocytosis of N and its ligands is a key mechanism by which N-mediated cell-cell signaling is developmentally regulated. We review here the recent findings that have highlighted the importance and complexity of this regulation.
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