spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online March 24, 2005
doi: 10.1242/10.1242/dev.01787

Development 132, 1961-1970 (2005)
Published by The Company of Biologists 2005
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rallis, C.
Right arrow Articles by Logan, M. P. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rallis, C.
Right arrow Articles by Logan, M. P. O.

Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo

Charalampos Rallis, Jo Del Buono and Malcolm P. O. Logan*

Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK

* Author for correspondence (e-mail: mlogan{at}nimr.mrc.ac.uk)

Accepted 14 February 2005

The limbs of the vertebrate embryo form at precise locations along the body and these positions are fixed across different species. The mechanisms that control this process are not understood. Ectopic expression of Tbx3, a transcriptional repressor that belongs to the Tbx2/3/4/5 subfamily of T-box transcriptional regulators, in the forelimb results in a rostral shift in the position of the limb along the main body axis. By contrast, a transcriptional activator form of Tbx3 shifts the limb to more caudal locations. We also show that dHand and Gli3, genes previously implicated in anteroposterior pre-patterning of the limb-forming region, are also involved in refining the position of the limbs. Our data suggest a new role for Tbx3 in positioning the limb along the main body axis through a genetic interplay between dHand and Gli3.

Key words: Limb development, Limb position, Tbx3, T-box, Gli3, dHand (Hand2), Chick




This article has been cited by other articles:


Home page
 DevelopmentHome page
L. Panman, A. Galli, N. Lagarde, O. Michos, G. Soete, A. Zuniga, and R. Zeller
Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling
Development, September 1, 2006; 133(17): 3419 - 3428.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. E. Govoni, S. K. Lee, R. B. Chadwick, H. Yu, Y. Kasukawa, D. J. Baylink, and S. Mohan
Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation
Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E128 - E136.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005