|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
First published online 30 November 2005
doi: 10.1242/dev.02187
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Division of Biology 139-74, California Institute of Technology, Pasadena, CA
91125, USA.
2 Department of Neuroscience, The Johns Hopkins University School of Medicine,
Baltimore, MD 21205, USA.
3 Howard Hughes Medical Institute, The Johns Hopkins University School of
Medicine, Baltimore, MD 21205, USA.
* Author for correspondence (e-mail: mbronner{at}caltech.edu)
Accepted 27 October 2005
In vertebrate embryos, neural crest cells migrate only through the anterior half of each somite while avoiding the posterior half. We demonstrate that neural crest cells express the receptor neuropilin 2 (Npn2), while its repulsive ligand semaphorin 3F (Sema3f) is restricted to the posterior-half somite. In Npn2 and Sema3f mutant mice, neural crest cells lose their segmental migration pattern and instead migrate as a uniform sheet, although somite polarity itself remains unchanged. Furthermore, Npn2 is cell autonomously required for neural crest cells to avoid Sema3f in vitro. These data show that Npn2/Sema3f signaling guides neural crest migration through the somite. Interestingly, neural crest cells still condense into segmentally arranged dorsal root ganglia in Npn2 nulls, suggesting that segmental neural crest migration and segmentation of the peripheral nervous system are separable processes.
Key words: Trunk neural crest migration, Sclerotome, Neuropilin 2, Semaphorin 3F, Mouse, Chick
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  Q. Schwarz, C. H. Maden, K. Davidson, and C. Ruhrberg Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia Development, June 1, 2009; 136(11): 1785 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Roffers-Agarwal and L. S. Gammill Neuropilin receptors guide distinct phases of sensory and motor neuronal segmentation Development, June 1, 2009; 136(11): 1879 - 1888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Schwarz, C. H. Maden, J. M. Vieira, and C. Ruhrberg Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification PNAS, April 14, 2009; 106(15): 6164 - 6169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Shnitsar and A. Borchers PTK7 recruits dsh to regulate neural crest migration Development, December 15, 2008; 135(24): 4015 - 4024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Schwarz, J. M. Vieira, B. Howard, B. J. Eickholt, and C. Ruhrberg Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells Development, May 1, 2008; 135(9): 1605 - 1613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kuriyama and R. Mayor Molecular analysis of neural crest migration Phil Trans R Soc B, April 12, 2008; 363(1495): 1349 - 1362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Durand, C. Robin, K. Bollerot, M. H. Baron, K. Ottersbach, and E. Dzierzak Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells PNAS, December 26, 2007; 104(52): 20838 - 20843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Paterson, D. Short, P. W. Flatman, J. R. Seckl, A. Aitken, and M. B. Dutia Changes in protein expression in the rat medial vestibular nuclei during vestibular compensation J. Physiol., September 15, 2006; 575(3): 777 - 788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Heanue and V. Pachnis From the Cover: Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes PNAS, May 2, 2006; 103(18): 6919 - 6924. [Abstract] [Full Text] [PDF]
|
|
