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First published online 3 May 2006
doi: 10.1242/dev.02402

Development 133, 2089-2094 (2006)
Published by The Company of Biologists 2006
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Meeting Review

Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity

Giacomo Cavalli

Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cédex 5, France.

e-mail: giacomo.cavalli{at}igh.cnrs.fr

SUMMARY

The epigenetic regulation of chromatin structure and composition has often been studied molecularly in the context of specific DNA-dependent processes. However, epigenetics also play important global roles in shaping and maintaining cell identity, and in patterning the body plan during normal development. Moreover, alterations in epigenetic regulation are involved in many diseases, including cancer. The advances in our understanding of the impact of epigenetics in development and disease were discussed at a recent Keystone symposium.




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© The Company of Biologists Ltd 2006