QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online 3 May 2006
doi: 10.1242/dev.02369

This Article Figures Only Full Text Full Text (PDF) An erratum has been published All Versions of this Article: dev.02369v1 133/11/2115    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Atkey, M. R. Articles by Nilson, L. A. Search for Related Content PubMed PubMed Citation Articles by Atkey, M. R. Articles by Nilson, L. A. Social Bookmarking                         What's this?

Capicua regulates follicle cell fate in the Drosophila ovary through repression of mirror

Department of Biology, McGill University, 1205 Doctor Penfield Avenue, Montreal, QC H3A 1B1, Canada.

^* Author for correspondence (e-mail: laura.nilson{at}mcgill.ca)

Accepted 17 March 2006

The dorsoventral axis of the Drosophila egg is established by dorsally localized activation of the epidermal growth factor receptor (Egfr) in the ovarian follicular epithelium. Subsequent positive- and negative-feedback regulation generates two dorsolateral follicle cell primordia that will produce the eggshell appendages. A dorsal midline domain of low Egfr activity between the appendage primordia defines their dorsal boundary, but little is known about the mechanisms that establish their ventral limit. We demonstrate that the transcriptional repressor Capicua is required cell autonomously in ventral and lateral follicle cells to repress dorsal fates, and functions in this process through the repression of mirror. Interestingly, ectopic expression of mirror in the absence of capicua is observed only in the anterior half of the epithelium. We propose that Capicua regulates the pattern of follicle cell fates along the dorsoventral axis by blocking the induction of appendage determinants, such as mirror, by anterior positional cues.

Key words: Drosophila, capicua, mirror, Follicle cells, Patterning

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J.-F. B. Lachance, M. F. Lomas, A. Eleiche, P. B. Kerr, and L. A. Nilson Graded Egfr activity patterns the Drosophila eggshell independently of autocrine feedback Development, September 1, 2009; 136(17): 2893 - 2902. [Abstract] [Full Text] [PDF]

				J. J. Zartman, J. S. Kanodia, L. S. Cheung, and S. Y. Shvartsman Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis Development, September 1, 2009; 136(17): 2903 - 2911. [Abstract] [Full Text] [PDF]

				J. Lembong, N. Yakoby, and S. Y. Shvartsman Pattern formation by dynamically interacting network motifs PNAS, March 3, 2009; 106(9): 3213 - 3218. [Abstract] [Full Text] [PDF]

				N. Yakoby, J. Lembong, T. Schupbach, and S. Y. Shvartsman Drosophila eggshell is patterned by sequential action of feedforward and feedback loops Development, January 15, 2008; 135(2): 343 - 351. [Abstract] [Full Text] [PDF]

				B. V. Shravage, G. Altmann, M. Technau, and S. Roth The role of Dpp and its inhibitors during eggshell patterning in Drosophila Development, June 15, 2007; 134(12): 2261 - 2271. [Abstract] [Full Text] [PDF]