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First published online 3 May 2006
doi: 10.1242/dev.02369

Development 133, 2115-2123 (2006)
Published by The Company of Biologists 2006
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Capicua regulates follicle cell fate in the Drosophila ovary through repression of mirror

Matthew R. Atkey, Jean-FranÇois Boisclair Lachance, Monica Walczak, Tahilia Rebello and Laura A. Nilson*

Department of Biology, McGill University, 1205 Doctor Penfield Avenue, Montreal, QC H3A 1B1, Canada.

* Author for correspondence (e-mail: laura.nilson{at}mcgill.ca)

Accepted 17 March 2006

The dorsoventral axis of the Drosophila egg is established by dorsally localized activation of the epidermal growth factor receptor (Egfr) in the ovarian follicular epithelium. Subsequent positive- and negative-feedback regulation generates two dorsolateral follicle cell primordia that will produce the eggshell appendages. A dorsal midline domain of low Egfr activity between the appendage primordia defines their dorsal boundary, but little is known about the mechanisms that establish their ventral limit. We demonstrate that the transcriptional repressor Capicua is required cell autonomously in ventral and lateral follicle cells to repress dorsal fates, and functions in this process through the repression of mirror. Interestingly, ectopic expression of mirror in the absence of capicua is observed only in the anterior half of the epithelium. We propose that Capicua regulates the pattern of follicle cell fates along the dorsoventral axis by blocking the induction of appendage determinants, such as mirror, by anterior positional cues.

Key words: Drosophila, capicua, mirror, Follicle cells, Patterning




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