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First published online 21 June 2006
doi: 10.1242/dev.02441
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1 Department of Human Genetics, University of Chicago, 920 E. 58th Street, CLSC
319 Chicago, IL 60637, USA.
2 Committee on Genetics, University of Chicago, 920 E. 58th Street, CLSC 319
Chicago, IL 60637, USA.
3 Departments of Pathology and Developmental and Cell Biology, University of
California, Irvine, D440 Medical Sciences I, Irvine, CA 92697-4800, USA.
4 Program in Developmental Biology, Howard Hughes Medical Institute, Baylor
College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
* Author for correspondence (e-mail: kmillen{at}genetics.bsd.uchicago.edu)
Accepted 12 May 2006
During embryogenesis, the isthmic organizer, a well-described signaling center at the junction of the mid-hindbrain, establishes the cerebellar territory along the anterior/posterior axis of the neural tube. Mechanisms specifying distinct populations within the early cerebellar anlage are less defined. Using a newly developed gene expression map of the early cerebellar anlage, we demonstrate that secreted signals from the rhombomere 1 roof plate are both necessary and sufficient for specification of the adjacent cerebellar rhombic lip and its derivative fates. Surprisingly, we show that the roof plate is not absolutely required for initial specification of more distal cerebellar cell fates, but rather regulates progenitor proliferation and cell position within the cerebellar anlage. Thus, in addition to the isthmus, the roof plate represents an important signaling center controlling multiple aspects of cerebellar patterning.
Key words: Roof plate, Dorsal midline, Signaling center, Cerebellum, Isthmic organizer, Lmx1a, Bmp, Neuronal specification, Proliferation, Mouse
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