spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 3 July 2006
doi: 10.1242/dev.02450

Development 133, 2925-2935 (2006)
Published by The Company of Biologists 2006
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow All Versions of this Article:
dev.02450v1
133/15/2925    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stigloher, C.
Right arrow Articles by Bally-Cuif, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stigloher, C.
Right arrow Articles by Bally-Cuif, L.

Segregation of telencephalic and eye-field identities inside the zebrafish forebrain territory is controlled by Rx3

Christian Stigloher1, Jovica Ninkovic1,*, Mary Laplante2, Andrea Geling1,{dagger}, Birgit Tannhäuser1, Stefanie Topp1, Hiroshi Kikuta2, Thomas S. Becker2, Corinne Houart3 and Laure Bally-Cuif1,{ddagger}

1 Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University-Munich, Trogerstrasse 4b, D-81675, Munich, Germany and GSF-National Research Center for Environment and Health, Department Zebrafish Neurogenetics, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany.
2 Sars Centre for Marine Molecular Biology, University of Bergen, Thormoehlensgt.55, N-5008 Bergen, Norway.
3 MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, SE1 9RT London, UK.

{ddagger} Author for correspondence (e-mail: bally{at}gsf.de)

Accepted 22 May 2006

Anteroposterior patterning of the vertebrate forebrain during gastrulation involves graded Wnt signaling, which segregates anterior fields (telencephalon and eye) from the diencephalon. How the telencephalic and retinal primordia are subsequently subdivided remains largely unknown. We demonstrate that at late gastrulation the Paired-like homeodomain transcription factor Rx3 biases cell specification choices towards the retinal fate within a population of bipotential precursors of the anterior forebrain: direct cell tracing demonstrates that retinal precursors acquire a telencephalic fate in embryos homozygous for the rx3-null allele ckhne2611, characterized by an enlarged telencephalon and a lack of eyes. Chimera analyses further indicate that this function of Rx3 is cell autonomous. Transfating of the eye field in the absence of Rx3 function correlates with a substantial posterior expansion of expression of the Wnt antagonist Tlc and the winged-helix transcription factor Foxg1. These results suggest that the process segregating the telencephalic and eye fields is isolated from diencephalic patterning, and is mediated by Rx3.

Key words: Zebrafish, Telencephalon, Eye field, Forebrain, Rx3




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
N. Nakaya, H.-S. Lee, Y. Takada, I. Tzchori, and S. I. Tomarev
Zebrafish Olfactomedin 1 Regulates Retinal Axon Elongation In Vivo and Is a Modulator of Wnt Signaling Pathway
J. Neurosci., July 30, 2008; 28(31): 7900 - 7910.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Bessa, M. J. Tavares, J. Santos, H. Kikuta, M. Laplante, T. S. Becker, J. L. Gomez-Skarmeta, and F. Casares
meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye
Development, March 1, 2008; 135(5): 799 - 803.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
H. Kikuta, M. Laplante, P. Navratilova, A. Z. Komisarczuk, P. G. Engstrom, D. Fredman, A. Akalin, M. Caccamo, I. Sealy, K. Howe, et al.
Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates
Genome Res., May 1, 2007; 17(5): 545 - 555.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. L. Andoniadou, M. Signore, E. Sajedi, C. Gaston-Massuet, D. Kelberman, A. J. Burns, N. Itasaki, M. Dattani, and J. P. Martinez-Barbera
Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain
Development, April 15, 2007; 134(8): 1499 - 1508.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006