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First published online September 12, 2006
doi: 10.1242/10.1242/dev.02568
Review |
1 Department of Molecular, Cell and Developmental Biology, Jonsson Comprehensive
Cancer Center, Institute for Stem Cell Biology and Medicine, University of
California, Los Angeles, CA 90095, USA.
2 Department of Pediatric Oncology, Dana-Farber Cancer Institute/Children's
Hospital, Harvard Medical School, Harvard Stem Cell Institute, Howard Hughes
Medical Institute, Boston, MA 02115, USA.
* Author for correspondence (e-mail: hmikkola{at}mcdb.ucla.edu)
Accepted 7 August 2006
SUMMARY
Hematopoietic stem cells (HSCs) develop during embryogenesis in a complex process that involves multiple anatomical sites. Once HSC precursors have been specified from mesoderm, they have to mature into functional HSCs and undergo self-renewing divisions to generate a pool of HSCs. During this process, developing HSCs migrate through various embryonic niches, which provide signals for their establishment and the conservation of their self-renewal ability. These processes have to be recapitulated to generate HSCs from embryonic stem cells. Elucidating the interactions between developing HSCs and their niches should facilitate the generation and expansion of HSCs in vitro to exploit their clinical potential.
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