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First published online 30 August 2006
doi: 10.1242/dev.02552

This Article Figures Only Full Text Full Text (PDF) Supplementary Material All Versions of this Article: dev.02552v1 133/19/3767    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miura, S. Articles by Mishina, Y. Search for Related Content PubMed PubMed Citation Articles by Miura, S. Articles by Mishina, Y. Social Bookmarking                         What's this?

BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites

¹ Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, 111 T. W. Alexander Drive, PO Box 12233, MD C4-10, C458, Research Triangle Park, NC 27709, USA.
² Department of Cell Biology, Duke University Medical Center, Durham NC 27710, USA.

^* Author for correspondence (e-mail: mishina{at}niehs.nih.gov)

Accepted 26 July 2006

Bmpr1a encodes the BMP type IA receptor for bone morphogenetic proteins (BMPs), including 2 and 4. Here, we use mosaic inactivation of Bmpr1a in the epiblast of the mouse embryo (Bmpr-MORE embryos) to assess functions of this gene in mesoderm development. Unlike Bmpr1a-null embryos, which fail to gastrulate, Bmpr-MORE embryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character within the primitive streak, resulting in a lateral expansion of somitic mesoderm to form multiple columns. Inhibition of FGF signaling restores the normal timing of recruitment of prospective paraxial mesoderm and partially rescues the development of somites. This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development.

Key words: Epiblast, Primitive streak, Paraxial mesoderm, Somites, BMP, FGF, Mouse

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