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First published online December 20, 2005
doi: 10.1242/10.1242/dev.02214
Review |
1 Department of Genetics, Cell Biology and Development, University of Minnesota,
Minneapolis, MN 55455, USA.
2 The Howard Hughes Medical Institute.
3 Department of Chemical Engineering and Materials Science, University of
Minnesota, Minneapolis, MN 55455, USA.
4 School of Mathematics and Digital Technology Center, University of Minnesota,
Minneapolis, MN 55455, USA.
5 Department of Zoology, 250 North Mills Street, University of Wisconsin,
Madison, WI 53706, USA.
* Authors for correspondence (e-mail: moconnor{at}mail.med.umn.edu and ssblair{at}wisc.edu)
SUMMARY
In the early Drosophila embryo, BMP-type ligands act as morphogens to suppress neural induction and to specify the formation of dorsal ectoderm and amnioserosa. Likewise, during pupal wing development, BMPs help to specify vein versus intervein cell fate. Here, we review recent data suggesting that these two processes use a related set of extracellular factors, positive feedback, and BMP heterodimer formation to achieve peak levels of signaling in spatially restricted patterns. Because these signaling pathway components are all conserved, these observations should shed light on how BMP signaling is modulated in vertebrate development.
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