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First published online 25 October 2006
doi: 10.1242/dev.02668

Development 133, 4619-4630 (2006)
Published by The Company of Biologists 2006
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A direct role for Sox10 in specification of neural crest-derived sensory neurons

Thomas J. Carney1, Kirsten A. Dutton1, Emma Greenhill1, Mariana Delfino-Machín1, Pascale Dufourcq2, Patrick Blader2 and Robert N. Kelsh1,*

1 Centre for Regenerative Medicine, Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.
2 Centre de Biologie du Développement, UMR5547, Université Paul Sabatier, bât. 4R3, 118, route de Narbonne, 31062 Toulouse, France.

* Author for correspondence (e-mail: bssrnk{at}bath.ac.uk)

Accepted 21 September 2006

sox10 is necessary for development of neural and pigment cell derivatives of the neural crest (NC). However, whereas a direct role for Sox10 activity has been established in pigment and glial lineages, this is more controversial in NC-derived sensory neurons of the dorsal root ganglia (DRGs). We proposed that sox10 functioned in specification of sensory neurons, whereas others suggested that sensory neuronal defects were merely secondary to absence of glia. Here we provide evidence that in zebrafish, early DRG sensory neuron survival is independent of differentiated glia. Critically, we demonstrate that Sox10 is expressed transiently in the sensory neuron lineage, and specifies sensory neuron precursors by regulating the proneural gene neurogenin1. Consistent with this, we have isolated a novel sox10 mutant that lacks glia and yet displays a neurogenic DRG phenotype. In conjunction with previous findings, these data establish the generality of our model of Sox10 function in NC fate specification.

Key words: Sox10, Neural crest, Fate specification, Determination, Dorsal root ganglion, Neurogenin, Zebrafish, Transgene, Waardenburg-Shah syndrome




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