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First published online 1 November 2006
doi: 10.1242/dev.02658

Development 133, 4737-4748 (2006)
Published by The Company of Biologists 2006
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Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse

Yoshifumi Yamaguchi1,2,*, Shigenobu Yonemura3 and Shinji Takada1,4,{dagger}

1 Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Myodaiji, Okazaki, 444-8787, Japan.
2 Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto, 606-8502, Japan.
3 Laboratory for Cellular Morphogenesis, Center for Developmental Biology, RIKEN, Kobe, 650-0047, Japan.
4 The Graduate University for Advanced Studies (SOKENDAI), Myodaiji, Okazaki, 444-8585, Japan.

{dagger} Author for correspondence (e-mail: stakada{at}nibb.ac.jp)

Accepted 22 September 2006

Duct epithelial structure is an essential feature of many internal organs, including exocrine glands and the kidney. The ducts not only mediate fluid transfer but also help to maintain homeostasis. For instance, fluids and solutes are resorbed from or secreted into the primary fluid flowing through the lumen of the ducts in the exocrine glands and kidneys. The molecular mechanism underlying the functional maturation of these ducts remains largely unknown. Here, we show that a grainyhead-related transcription factor, CP2-like 1 (CP2L1), is required for the maturation of the ducts of the salivary gland and kidney. In the mouse, Cp2l1 is specifically expressed in the developing ducts of a number of exocrine glands, including the salivary gland, as well as in those of the kidney. In Cp2l1-deficient mice, the expression of genes directly involved in functional maturation of the ducts was specifically reduced in both the salivary gland and kidney, indicating that Cp2l1 is required for the differentiation of duct cells. Furthermore, the composition of saliva and urine was abnormal in these mice. These results indicate that Cp2l1 expression is required for normal duct development in both the salivary gland and kidney.

Key words: Grainyhead, Organogenesis, Kidney, Salivary gland






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