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First published online 8 November 2006
doi: 10.1242/dev.02685

Development 133, 4849-4859 (2006)
Published by The Company of Biologists 2006
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Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size

Ya-Chu Hsu1,2, John J. Willoughby1, Arne K. Christensen1,2 and Abbie M. Jensen1,2,*

1 Department of Biology and University of Massachusetts, Amherst, MA 01003, USA.
2 Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA.

* Author for correspondence (e-mail: ajensen{at}bio.umass.edu)

Accepted 5 October 2006

Establishment of apical-basal cell polarity has emerged as an important process during development, and the Crumbs complex is a major component of this process in Drosophila. By comparison, little is known about the role of Crumbs (Crb) proteins in vertebrate development. We show that the FERM protein Mosaic Eyes (Moe) is a novel regulatory component of the Crumbs complex. Moe coimmunoprecipitates with Ome/Crb2a and Nok (Pals1) from adult eye and in vitro interaction experiments suggest these interactions are direct. Morpholino knockdown of ome/crb2a phenocopies the moe mutations. Moe and Crumbs proteins colocalize apically and this apical localization requires reciprocal protein function. By performing genetic mosaic analyses, we show that moe- rod photoreceptors have greatly expanded apical structures, suggesting that Moe is a negative regulator of Crumbs protein function in photoreceptors. We propose that Moe is a crucial regulator of Crumbs protein cell-surface abundance and localization in embryos.

Key words: Inner segment, Outer segment, Renewal, Morphogenesis, Zebrafish




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