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First published online January 12, 2006
doi: 10.1242/10.1242/dev.02209

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Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order

¹ Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA.
² Division of Morphogenesis, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University 2-2-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan.
³ Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

^* Authors for correspondence (e-mail: egrove{at}bsd.uchicago.edu; myoshida{at}kaiju.medic.kumamoto-u.ac.jp)

Accepted 10 November 2005

Cajal-Retzius (CR) cells, the predominant source of reelin in developing neocortex, are thought to be essential for the inside out formation of neocortical layers. Fate mapping revealed that a large population of neocortical CR cells arises from the cortical hem. To investigate the function of CR cells, we therefore genetically ablated the hem. Neocortical CR cells were distributed beneath the pial surface in control mice, but were virtually absent in hem-ablated mice from embryonic day (E) 10.5 until birth. CR cells derived from other sources did not invade the neocortical primordium to compensate for hem loss. We predicted that neocortical layers would be inverted in hem-ablated animals, as in reeler mice, deficient in reelin signaling. Against expectation, layers showed the standard order. Low levels of reelin in the cortical primordium, or diffusion of reelin from other sites, may have allowed lamination to proceed. Our findings indicate, however, that the sheet of reelin-rich CR cells that covers the neocortical primordium is not required to direct layer order.

Key words: Mouse, Cajal-Retzius cells, Neocortex

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Reelin-in neocortical layers

Development 2006 133: e302. [Full Text]  

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