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First published online 5 January 2006
doi: 10.1242/dev.02218

Development 133, 547-557 (2006)
Published by The Company of Biologists 2006
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Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development

Jenifer Croce1,2, Louise Duloquin1, Guy Lhomond1, David R. McClay2 and Christian Gache1,*

1 Unité de Biologie du Développement, UMR 7009, CNRS, Université Pierre et Marie Curie, Observatoire Océanologique, 06230 Villefranche-sur-Mer, France.
2 Developmental, Cell and Molecular Biology Group, Box 91000, Duke University, Durham, NC 27708, USA.

* Author for correspondence (e-mail: gache{at}obs-vlfr.fr)

Accepted 23 November 2005

Wnt signaling pathways play key roles in numerous developmental processes both in vertebrates and invertebrates. Their signals are transduced by Frizzled proteins, the cognate receptors of the Wnt ligands. This study focuses on the role of a member of the Frizzled family, Fz5/8, during sea urchin embryogenesis. During development, Fz5/8 displays restricted expression, beginning at the 60-cell stage in the animal domain and then from mesenchyme blastula stage, in both the animal domain and a subset of secondary mesenchyme cells (SMCs). Loss-of-function analyses in whole embryos and chimeras reveal that Fz5/8 is not involved in the specification of the main embryonic territories. Rather, it appears to be required in SMCs for primary invagination of the archenteron, maintenance of endodermal marker expression and apical localization of Notch receptors in endodermal cells. Furthermore, among the three known Wnt pathways, Fz5/8 appears to signal via the planar cell polarity pathway. Taken together, the results suggest that Fz5/8 plays a crucial role specifically in SMCs to control primary invagination during sea urchin gastrulation.

Key words: Sea urchin, Frizzled, Wnt, PCP pathway, Notch signaling, Gastrulation, Primary invagination


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A new conserved role for Wnts in gastrulation?

Development 2006 133: e303. [Full Text]  



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E. Rottinger, A. Saudemont, V. Duboc, L. Besnardeau, D. McClay, and T. Lepage
FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development
Development, January 15, 2008; 135(2): 353 - 365.
[Abstract] [Full Text] [PDF]


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