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First published online February 9, 2006
doi: 10.1242/10.1242/dev.02276
Review |
1 Institute of Molecular Biology, University of Oregon, Eugene, OR 97403,
USA.
2 Institute of Biochemistry, ETH Zürich, Hönggerberg, 8093
Zürich, Switzerland.
* Author for correspondence (e-mail: thimo.kurz{at}bc.biol.ethz.ch)
SUMMARY
The ubiquitin protein conjugation system tags proteins with the small polypeptide ubiquitin. Most poly-ubiquitinated proteins are recognized and degraded by the proteasome, a large multi-subunit protease. Ubiquitin-dependent protein degradation is used as a regulatory tool for many essential processes, the best studied of which is eukaryotic cell cycle progression. More recently, genetic studies in C. elegans have identified multiple roles for the ubiquitin system in early development, where ubiquitin-dependent protein degradation governs such diverse events as passage through meiosis, cytoskeletal regulation and cell fate determination.
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