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First published online February 9, 2006
doi: 10.1242/10.1242/dev.02266
1 Institute of Genetics, Biological Research Center, Hungarian Academy of
Sciences, H-6726 Szeged, Temesvári krt. 62, Hungary.
2 Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai
School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
3 European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg,
Germany.
* Authors for correspondence (e-mail: mihaly{at}brc.hu; marek.mlodzik{at}mssm.edu)
Accepted 28 December 2005
Formins are involved in a wide range of cellular processes that require the remodeling of the actin cytoskeleton. Here, we have analyzed a novel Drosophila formin, belonging to the recently described DAAM subfamily. In contrast to previous assumptions, we show that DAAM plays no essential role in planar cell polarity signaling, but it has striking requirements in organizing apical actin cables that define the taenidial fold pattern of the tracheal cuticle. These observations provide evidence the first time that the function of the taenidial organization is to prevent the collapse of the tracheal tubes. Our results indicate that although DAAM is regulated by RhoA, it functions upstream or parallel to the non-receptor tyrosine kinases Src42A and Tec29 to organize the actin cytoskeleton and to determine the cuticle pattern of the Drosophila respiratory system.
Key words: Formin, DAAM, Actin cytoskeleton, Tracheal cuticle, Src kinases, Drosophila
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