spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 22 February 2006
doi: 10.1242/dev.02287

Development 133, 1287-1297 (2006)
Published by The Company of Biologists 2006
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow All Versions of this Article:
dev.02287v1
133/7/1287    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MacWilliams, H.
Right arrow Articles by Ceccarelli, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MacWilliams, H.
Right arrow Articles by Ceccarelli, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

A retinoblastoma ortholog controls stalk/spore preference in Dictyostelium

Harry MacWilliams1,*, Kimchi Doquang1,2, Roberto Pedrola3, Gytha Dollman1, Daniela Grassi3, Thomas Peis1, Adrian Tsang2 and Adriano Ceccarelli3

1 Biozentrum der Ludwig-Maximilians-Universität, Grosshadernerstrasse 2, 82152 Planegg-Martinsried, Germany.
2 Centre for Structural and Functional Genomics, Concordia University Montreal, Quebec H4B 1R6, Canada.
3 Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Ospedale S.Luigi, 10043 Orbassano, Torino, Italy.

* Author for correspondence (e-mail: macw{at}zi.biologie.uni-muenchen.de)

Accepted 18 January 2006

We describe rblA, the Dictyostelium ortholog of the retinoblastoma susceptibility gene Rb. In the growth phase, rblA expression is correlated with several factors that lead to `preference' for the spore pathway. During multicellular development, expression increases 200-fold in differentiating spores. rblA-null strains differentiate stalk cells and spores normally, but in chimeras with wild type, the mutant shows a strong preference for the stalk pathway. rblA-null cells are hypersensitive to the stalk morphogen DIF, suggesting that rblA normally suppresses the DIF response in cells destined for the spore pathway. rblA overexpression during growth leads to G1 arrest, but as growing Dictyostelium are overwhelmingly in G2 phase, rblA does not seem to be important in the normal cell cycle. rblA-null cells show reduced cell size and a premature growth-development transition; the latter appears anomalous but may reflect selection pressures acting on social ameba.

Key words: Ameba, Cell cycle, Differentiation, Evolution


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in Development:

Signal changes for Dicty Rb

Development 2006 133: e703. [Full Text]  



This article has been cited by other articles:


Home page
 DevelopmentHome page
T. Muramoto and J. R. Chubb
Live imaging of the Dictyostelium cell cycle reveals widespread S phase during development, a G2 bias in spore differentiation and a premitotic checkpoint
Development, May 1, 2008; 135(9): 1647 - 1657.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006