QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online May 16, 2007
doi: 10.1242/10.1242/dev.001164

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Harris, K. E. Articles by Beckendorf, S. K. Search for Related Content PubMed PubMed Citation Articles by Harris, K. E. Articles by Beckendorf, S. K. Social Bookmarking                         What's this?

Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

^* Author for correspondence (e-mail: beckendo{at}berkeley.edu)

Accepted 11 March 2007

Guided cell migration is necessary for the proper function and development of many tissues, one of which is the Drosophila embryonic salivary gland. Here we show that two distinct Wnt signaling pathways regulate salivary gland migration. Early in migration, the salivary gland responds to a WNT4-Frizzled signal for proper positioning within the embryo. Disruption of this signal, through mutations in Wnt4, frizzled or frizzled 2, results in misguided salivary glands that curve ventrally. Furthermore, disruption of downstream components of the canonical Wnt pathway, such as dishevelled or Tcf, also results in ventrally curved salivary glands. Analysis of a second Wnt signal, which acts through the atypical Wnt receptor Derailed, indicates a requirement for Wnt5 signaling late in salivary gland migration. WNT5 is expressed in the central nervous system and acts as a repulsive signal, needed to keep the migrating salivary gland on course. The receptor for WNT5, Derailed, is expressed in the actively migrating tip of the salivary glands. In embryos mutant for derailed or Wnt5, salivary gland migration is disrupted; the tip of the gland migrates abnormally toward the central nervous system. Our results suggest that both the Wnt4-frizzled pathway and a separate Wnt5-derailed pathway are needed for proper salivary gland migration.

Key words: Derailed, WNT5, WNT4, RYK, Migration, Salivary gland

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. Lyu, R. L. Wesselschmidt, and W. Lu Cdc37 Regulates Ryk Signaling by Stabilizing the Cleaved Ryk Intracellular Domain J. Biol. Chem., May 8, 2009; 284(19): 12940 - 12948. [Abstract] [Full Text] [PDF]

				J. Caverzasio Non-Canonical Wnt Signaling: What Is Its Role in Bone? IBMS BoneKEy, March 1, 2009; 6(3): 107 - 115. [Abstract] [Full Text] [PDF]

				V. Maybeck and K. Roper A Targeted Gain-of-Function Screen Identifies Genes Affecting Salivary Gland Morphogenesis/Tubulogenesis in Drosophila Genetics, February 1, 2009; 181(2): 543 - 565. [Abstract] [Full Text] [PDF]

				R. van Amerongen, A. Mikels, and R. Nusse Alternative Wnt Signaling Is Initiated by Distinct Receptors Sci. Signal., September 2, 2008; 1(35): re9 - re9. [Abstract] [Full Text] [PDF]